{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:13:20Z","timestamp":1767849200614,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T00:00:00Z","timestamp":1512172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26462489"],"award-info":[{"award-number":["26462489"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25462593"],"award-info":[{"award-number":["25462593"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Problem<\/jats:title>Is an abnormal increase or decrease of M1\/M2 macrophages observed in the deciduae of miscarriages with normal fetal chromosome (MN<\/jats:styled-content>)?<\/jats:p><\/jats:sec>Methods of study<\/jats:title>Deciduae of 18 MN<\/jats:styled-content> and 26 miscarriages with abnormal fetal chromosome (MA<\/jats:styled-content>) were obtained. Additionally, deciduae from 15 women whose pregnancies ended in induced abortions (IA<\/jats:styled-content>) and endometriums at the mid\u2010luteal phase from 19 non\u2010pregnant women endomeriums of mid\u2010luteal phases (EM<\/jats:styled-content>) were obtained. Macrophages were analyzed by flow cytometry using monoclonal antibodies for CD<\/jats:styled-content>68, HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content>, and CD<\/jats:styled-content>163.<\/jats:p><\/jats:sec>Results<\/jats:title>M1 macrophages, defined as CD<\/jats:styled-content>68+<\/jats:sup>HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content>+<\/jats:sup>CD<\/jats:styled-content>163\u2212<\/jats:sup> cells, increased in MN<\/jats:styled-content> compared with MA<\/jats:styled-content> or IA<\/jats:styled-content>. M2 macrophages, defined as CD<\/jats:styled-content>68+<\/jats:sup>HLA<\/jats:styled-content>\u2010DR<\/jats:styled-content>\u2212<\/jats:sup>CD<\/jats:styled-content>163+<\/jats:sup> cells, increased in the deciduae of MA<\/jats:styled-content> and IA<\/jats:styled-content> compared with EM<\/jats:styled-content>. However, this increase was not observed in the deciduae of MN<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our findings of phenotypic characters of decidual macrophages in MN<\/jats:styled-content> provide additional evidence that M2 polarization is favorable for the maintenance of early stages of pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12791","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T07:02:46Z","timestamp":1512198166000},"source":"Crossref","is-referenced-by-count":22,"title":["Decidual CD<\/scp>68+<\/sup>HLA<\/scp>\u2010DR<\/scp>+<\/sup>CD<\/scp>163\u2212<\/sup> M1 macrophages increase in miscarriages with normal fetal chromosome"],"prefix":"10.1111","volume":"79","author":[{"given":"Shigeki","family":"Shimada","sequence":"first","affiliation":[{"name":"Mommy's Clinic Chitose Chitose 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