{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:44:06Z","timestamp":1774982646860,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C is the only classical <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010I antigen expressed on trophoblast. We hypothesized that the alloimmune response to paternal <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C plays a role in unexplained recurrent miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>In a case\u2010control design, we included 100 women with at least three unexplained consecutive miscarriages along with their partners and children. For the first control group, we included 90 women with an uneventful singleton pregnancy without pregnancy complications in their history along with their children. The second control group consisted of 425 families. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*07 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*17 frequencies, which are the most immunogenic <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C antigens, along with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C mismatches, and the presence of specific <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies in the mother were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*07 mismatches were significantly increased in couples with recurrent miscarriage compared to control subjects (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.016, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.008, respectively). The incidence of child\u2010specific <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*07\/<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*17 antibodies was increased in women with recurrent miscarriage (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results show that <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C incompatibility between couples is significantly associated with unexplained recurrent miscarriage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12797","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:29:40Z","timestamp":1512469780000},"source":"Crossref","is-referenced-by-count":19,"title":["Paternal <scp>HLA<\/scp>\u2010C is a risk factor in unexplained recurrent miscarriage"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0264-2272","authenticated-orcid":false,"given":"Tess","family":"Meuleman","sequence":"first","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert W.","family":"Haasnoot","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan M. M.","family":"van Lith","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Verduijn","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitty W. M.","family":"Bloemenkamp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Leiden University Medical Centre  Leiden The Netherlands"},{"name":"Department of Obstetrics, Wilhelmina Children Hospital Birth Centre Division Woman and Baby Utrecht University Medical Centre  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frans H. J.","family":"Claas","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1991.tb00697.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1005330"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2006.00599.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.02.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43998"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2016.03.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-05-0334"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta20410"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-154"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32835585dc"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152635"},{"key":"e_1_2_6_14_1","first-page":"209","article-title":"Intrauterine growth and intrauterine growth curves","volume":"37","author":"Kloosterman GJ","year":"1969","journal-title":"Maandschr Kindergeneeskd"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00384-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01032.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01608.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.28.706.49"},{"key":"e_1_2_6_19_1","first-page":"4","volume-title":"Papers on human genetics","author":"Weinberg W","year":"1963"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00382-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01348.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1955.tb01285.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12109"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1121"},{"key":"e_1_2_6_25_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jri.2015.12.001","article-title":"Increased complement C4d deposition at the maternal\u2010fetal interface in unexplained recurrent miscarriage","volume":"113","author":"Meuleman T","year":"2015","journal-title":"J Reprod Immunol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-014-1571-0"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016806"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2010.05.006"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-610857"},{"key":"e_1_2_6_30_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7326\/L15-5137-3","article-title":"Low\u2010Molecular\u2010Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss","volume":"163","author":"Schleussner E","year":"2015","journal-title":"Ann Intern Med"},{"key":"e_1_2_6_31_1","first-page":"1","article-title":"Aspirin and\/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia","volume":"7","author":"Jong PG","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181deba40"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075690"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21157"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a137325"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2005.01.001"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302506"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66458-6"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00209-9"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328344c3f7"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:27:43Z","timestamp":1695889663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/aji.12797"],"URL":"https:\/\/doi.org\/10.1111\/aji.12797","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]},"article-number":"e12797"}}