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Maternal <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T cells were depleted with anti\u2010<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> antibodies. <jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content> was induced with lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> was confirmed using flow cytometry. Preterm birth rate was evaluated. Offspring neurologic sequelae were assessed by Nissl staining, immune arrays, confirmatory individual TaqMan<jats:sup>\u00ae<\/jats:sup> gene assays, and neurobehavioral tests. <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> did not significantly prevent <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010induced preterm birth but improved neurobehavioral performance (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and increased cortical neuronal density (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) in <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010exposed pups compared to controls. These changes were associated with decreased <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>3 and <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>10 and increased <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 in <jats:styled-content style=\"fixed-case\">DEP LPS<\/jats:styled-content>\u2010exposed mice. We demonstrate that <jats:styled-content style=\"fixed-case\">DEP<\/jats:styled-content> reduces perinatal brain injury following <jats:styled-content style=\"fixed-case\">IUI<\/jats:styled-content>. This supports a role for maternal <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> T\u2010cell trafficking in placenta in mediating perinatal brain injury separate from preterm birth mechanisms.<\/jats:p>","DOI":"10.1111\/aji.12798","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T10:29:57Z","timestamp":1512469797000},"source":"Crossref","is-referenced-by-count":25,"title":["Maternal <scp>CD<\/scp>8<sup>+<\/sup> T\u2010cell depletion alleviates intrauterine inflammation\u2010induced perinatal brain injury"],"prefix":"10.1111","volume":"79","author":[{"given":"Jun","family":"Lei","sequence":"first","affiliation":[{"name":"Integrated Research Center for Fetal Medicine Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Xie","sequence":"additional","affiliation":[{"name":"Integrated 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