{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:37:32Z","timestamp":1780731452134,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Recurrent pregnancy loss (RPL) potentially involves an abnormal maternal inflammatory response. We investigated whether children of mothers with a history of RPL are at an increased risk for childhood gastrointestinal (GI) morbidity, with a specific focus on inflammatory bowel diseases (IBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>A population\u2010based cohort analysis comparing the risk for long\u2010term GI morbidity in children born to mothers with and without a history of RPL. Gastrointestinal (GI) morbidity included hospitalizations involving a pre\u2010defined set of ICD\u20109 codes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 242 186 newborns met the inclusion criteria; 5% of which were offspring to mothers with a history of RPL. Gastrointestinal morbidity was significantly more common in the RPL group (6.6% vs 5.3%). Specifically, offspring to mothers with a history of RPL had significantly higher rates of IBD (2.1% vs 1.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal history of RPL is associated with an increased risk for pediatric GI morbidity in the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12799","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T10:51:30Z","timestamp":1513421490000},"source":"Crossref","is-referenced-by-count":8,"title":["Maternal history of recurrent pregnancy loss is associated with increased risk for long\u2010term pediatric gastrointestinal morbidity in the offspring"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8737-7796","authenticated-orcid":false,"given":"Yael","family":"Lichtman","sequence":"first","affiliation":[{"name":"Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idit","family":"Segal","sequence":"additional","affiliation":[{"name":"Israel Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella","family":"Landau","sequence":"additional","affiliation":[{"name":"Israel Ministry of Health  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asnat","family":"Walfisch","sequence":"additional","affiliation":[{"name":"Soroka University Medical Center  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu042"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2014-132672"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12329"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00436.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0699-z"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal084"},{"key":"e_1_2_5_9_1","first-page":"1","article-title":"IL\u201010 in humans: lessons from the gut, IL\u201010\/IL\u201010 receptor deficiencies, and IL\u201010 polymorphisms","volume":"380","author":"Engelhardt KR","year":"2014","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu043"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00059-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00434.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2005\/269076"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21868"},{"key":"e_1_2_5_15_1","unstructured":"Israel in Figures.http:\/\/www.cbs.gov.il\/reader\/publications\/israel_fig_e.htm. 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