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Discovered almost a quarter century ago, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A is known to have poor biologic activity when acting alone, but attains robust actions when working synergistically with potent mediators of proinflammatory immune responses, such as <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20108. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A is produced by specialized innate immune cells that protect host barriers from the outside world. Like sentries, these innate immune cells can \u201csound the alarm\u201d through increased production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A, causing activation and recruitment of primed neutrophils and monocytes when pathogens escape initial host defenses. In this way, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A promulgates mechanisms responsible for pathogen death and clearance. However, when <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A pathways are triggered during fetal development, due to chorioamnionitis or in utero inflammatory conditions, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A can instigate and\/or exacerbate fetal inflammatory responses that increase neonatal morbidities and mortality associated with common neonatal conditions such as sepsis, bronchopulmonary dysplasia (<jats:styled-content style=\"fixed-case\">BPD<\/jats:styled-content>), patent ductus arteriosus (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>), and necrotizing enterocolitis (<jats:styled-content style=\"fixed-case\">NEC<\/jats:styled-content>). This review details the ontogeny of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in the fetus and newborn, discusses how derangements in its production can lead to pathology, and describes known and evolving therapies that may attenuate <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\u2013mediated human conditions.<\/jats:p>","DOI":"10.1111\/aji.12800","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T10:50:45Z","timestamp":1513421445000},"source":"Crossref","is-referenced-by-count":47,"title":["<scp>IL<\/scp>\u201017 in neonatal health and disease"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-7051","authenticated-orcid":false,"given":"Shelley M.","family":"Lawrence","sequence":"first","affiliation":[{"name":"Division of Neonatal\u2010Perinatal Medicine Department of Pediatrics College of Medicine University of California, San Diego  La Jolla 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