{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:36Z","timestamp":1790723676269,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Toll\u2010like (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>) receptor genetic variants have been implicated in bacterial vaginosis (<jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>). We determined whether <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content> variants are associated with fastidious <jats:styled-content style=\"fixed-case\">BV<\/jats:styled-content>\u2010associated microbes that are linked with infertility following pelvic inflammatory disease (<jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p><jats:italic>Sneathia<\/jats:italic> spp., <jats:italic>Atopobium vaginae<\/jats:italic>,<jats:styled-content style=\"fixed-case\"> BVAB<\/jats:styled-content>1, and <jats:italic>Ureaplasma urealyticum<\/jats:italic> were measured in 250 women from the <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content> Evaluation and Clinical Health (<jats:styled-content style=\"fixed-case\">PEACH<\/jats:styled-content>) study. Relative risk (<jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>) and 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were calculated adjusting for chlamydia and gonorrhea. Principal component analysis was used to adjust for population stratification. A false discovery rate q\u2010value of 0.05 was significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2\u20101733C&gt;A (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2\u2010616A&gt;G (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) were associated with cervical <jats:italic>A.\u00a0vaginae<\/jats:italic>. <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2\u20101733C&gt;A and <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>6\u2010438C&gt;T were associated with <jats:italic>A.\u00a0vaginae<\/jats:italic> detection in the endometrium, but this was not significant after adjustment for multiple comparisons (<jats:styled-content style=\"fixed-case\">FDR<\/jats:styled-content> q\u2010value\u00a0=\u00a00.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Host gene variants in <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>2 signaling pathways were modestly associated with cervical <jats:italic>A.\u00a0vaginae<\/jats:italic> in women with clinical <jats:styled-content style=\"fixed-case\">PID<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12804","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T10:32:40Z","timestamp":1514543560000},"source":"Crossref","is-referenced-by-count":21,"title":["Toll\u2010like receptor variants and cervical <i>Atopobium vaginae<\/i> infection in women with pelvic inflammatory disease"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-1815","authenticated-orcid":false,"given":"Brandie D.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Epidemiology and 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