{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:33Z","timestamp":1787013813380,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T00:00:00Z","timestamp":1514592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003454","name":"Guangxi Zhuang Region Health Department","doi-asserted-by":"publisher","award":["Z2015177"],"award-info":[{"award-number":["Z2015177"]}],"id":[{"id":"10.13039\/501100003454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2014GXNSFAA118189"],"award-info":[{"award-number":["2014GXNSFAA118189"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>\n                      The aim of this research was to investigate the effects of the intrauterine perfusion of\n                      <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>\n                      before a frozen\u2010thawed embryo transfer (\n                      <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>\n                      ) in women with different implantation failure numbers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of Study<\/jats:title>\n                    <jats:p>\n                      This was a retrospective analysis of patients undergoing\n                      <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>\n                      who received an intrauterine injection\n                      <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>\n                      1000\n                      <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\n                      before embryo transfer. The groups included women with their first implantation failure (A group, n\u00a0=\u00a026), second implantation failure (B group, n\u00a0=\u00a0122), and three or more failures (C group, n\u00a0=\u00a077). Corresponding control groups (no infusion) were also included. The pregnancy rates were compared among these groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After intrauterine injection\n                      <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>\n                      , the biochemical pregnancy rates were 92.30%, 63.11%, 49.02%, and the clinical pregnancy rates were 76.92%, 54.91%, 48.05%, in the A, B, and C groups, respectively. The biochemical and clinical pregnancy rates were significantly higher in the A group than in the other groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). The clinical pregnancy rates of the A and C groups were significantly higher than in the corresponding (no infusion) control groups (76.92% vs 56.81% and 48.05% vs 33.33%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Pregnancy rates decreased with the number of transplant failures. The intrauterine administration of\n                      <jats:styled-content style=\"fixed-case\">hCG<\/jats:styled-content>\n                      before\n                      <jats:styled-content style=\"fixed-case\">FET<\/jats:styled-content>\n                      significantly improved the pregnancy rates, especially after one and three or more implantation failures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.12809","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T02:16:41Z","timestamp":1514600201000},"source":"Crossref","is-referenced-by-count":20,"title":["Effects of intrauterine perfusion of human chorionic gonadotropin in women with different implantation failure numbers"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-4970","authenticated-orcid":false,"given":"Pinxiu","family":"Huang","sequence":"first","affiliation":[{"name":"Guangxi Medical 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