{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:33:16Z","timestamp":1792319596555,"version":"4.4.0"},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The immune protective effects of chitooligosaccharides (<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>s) on mouse genital tract infected by <jats:italic>Chlamydia trachomatis<\/jats:italic> (Ct) were unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The minimum effective\/infective dose was obtained by establishing the murine model of the genital tract infected by Ct. The model mice were treated with different doses (0.1, 0.2, and 0.3\u00a0g\/kg,) of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>s and 0.9% saline, and the serum immunoglobulin G (IgG) antibody and interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201011 levels were then assayed. The healthy mice were used as the control. After 1\u00a0week of immunity, a double\u2010effective\/infective dose of Ct was used to attack the genital tract. After 10\u00a0days of experiment, the mice were killed, their spleen and thymus indexes were determined, and the pathological changes in their genital tract were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>s increased the serum IgG antibody, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201011 levels, and spleen and thymus indexes but decreased the positive infection rate and inclusion body formation with Ct.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>s could induce immune protection on the Ct\u2010infected mouse genital tract and might be used as an alternative drug for the treatment of genital tract infected with Ct.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12815","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T16:19:06Z","timestamp":1516292346000},"source":"Crossref","is-referenced-by-count":3,"title":["Immune protective effects of chitooligosaccharides on mice genital tract infected by <i>Chlamydia trachomatis<\/i>"],"prefix":"10.1111","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8596-2329","authenticated-orcid":false,"given":"Li","family":"Qian","sequence":"first","affiliation":[{"name":"College of medical technology Shanghai University of Medicine &amp; Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-2901","authenticated-orcid":false,"given":"Linjun","family":"Chen","sequence":"additional","affiliation":[{"name":"College of medical technology Shanghai University of Medicine &amp; Health Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/338569"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06886-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2006.12.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.07.051"},{"key":"e_1_2_6_6_1","first-page":"951","article-title":"Chitooligosaccharide promotes immune organ development in broiler chickens and reduces serum lipid levels","volume":"32","author":"Li S","year":"2017","journal-title":"Histol Histopathol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2015.02.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.03.111"},{"key":"e_1_2_6_9_1","first-page":"692","article-title":"Preliminary study on the murine model for genital infection with Chlamydia trachomatis","volume":"27","author":"Wang LD","year":"2011","journal-title":"Chinese J Zoonoses"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12815","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12815","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:48:16Z","timestamp":1695491296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/aji.12815"],"URL":"https:\/\/doi.org\/10.1111\/aji.12815","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,18]]},"article-number":"e12815"}}