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Melatonin acts as a broad\u2010spectrum antioxidant, powerful free radical scavenger, anti\u2010inflammatory agent, anticarcinogenic factor, sleep inducer and regulator of the circadian rhythm, and potential immunoregulator. Melatonin and reproductive system are interrelated under both physiological and pathological conditions. Oxidative stress, inflammation, and immune dysregulation are associated with the pathogenesis of the female reproductive system which causes endometriosis (<jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>), recurrent spontaneous abortion (<jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>), and polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). Accumulating studies have indicated that melatonin plays pleiotropic and essential roles in these obstetrical and gynecological disorders and would be a candidate therapeutic drug to regulate inflammation and immune function and protect special cells or organs. Here, we systematically review the pleiotropic roles of melatonin in <jats:styled-content style=\"fixed-case\">EMS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RSA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> to explore its pathological implications and treatment potential.<\/jats:p>","DOI":"10.1111\/aji.12839","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T09:53:00Z","timestamp":1519897980000},"source":"Crossref","is-referenced-by-count":41,"title":["Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome"],"prefix":"10.1111","volume":"80","author":[{"given":"Hui\u2010Li","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology, Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of 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