{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:35:11Z","timestamp":1790487311847,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG3OD023285"],"award-info":[{"award-number":["UG3OD023285"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Autism spectrum disorder (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>) is one of the most commonly diagnosed neurodevelopmental disorders in the United States. While <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> can be significantly influenced by genetics, prenatal exposure to maternal infections has also been implicated in conferring risk. Despite this, the effects of several important maternal pathogens, such as cytomegalovirus (<jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>) and herpes simplex virus 2 (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>2), remain unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>We tested whether maternal <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>2 sero\u2010positivity was associated with <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> symptoms in children. <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> was used to assay for <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> IgG and <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>2 IgG in serum from the mothers of 82 children whose <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> symptoms were assessed at 3\u20106\u00a0years of age using the Social Responsiveness Scale version 2 (<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>\u20102).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Associations between maternal viral serostatus and <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>\u20102 scores were estimated using linear regression with covariate adjustments. The children of mothers sero\u2010positive for <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content>, but not for <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>2, had <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>\u20102 scores 3.6\u20104.2 points higher, depending on the adjustment model, than sero\u2010negative women, a significant finding, robust to several statistical adjustments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that maternal <jats:styled-content style=\"fixed-case\">CMV<\/jats:styled-content> infections may influence <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> symptoms. These findings are being further evaluated in ongoing prospective studies with larger population samples.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12840","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T09:16:59Z","timestamp":1520587019000},"source":"Crossref","is-referenced-by-count":49,"title":["Maternal cytomegalovirus sero\u2010positivity and autism symptoms in children"],"prefix":"10.1111","volume":"79","author":[{"given":"Brooke L.","family":"Slawinski","sequence":"first","affiliation":[{"name":"Department of Psychology College of Social Sciences Michigan State University  East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Talge","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics College of Human Medicine Michigan State University  East Lansing MI 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