{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:53:02Z","timestamp":1790049182550,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"FIR (Finanziamento della Ricerca d'Ateneo) 2014"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Chronic endometritis (CE) is usually asymptomatic and different studies demonstrated the relation with infertility and recurrent pregnancy loss. Altered regulation of protein\u2010encoding genes in CE has been demonstrated, but no evidence about the involvement of microRNAs in the pathology is present in literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>In the endometrium from 15 women with CE and 15 healthy women, by RT\u2010qPCR single assays, we investigated some microRNAs targeting IL11, CCL4, IGF1, and IGFBP1, which mRNAs had been found differentially expressed in endometrium of women affected by CE. The expression of IGF1 and IL11, targets of the deregulated microRNAs, has been analyzed in the same endometrium samples. We assessed the expression profiles of the deregulated microRNAs in the serum of the same patients validating their ability as biomarkers by statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We demonstrated the upregulation of miR\u201027a\u20103p and miR\u2010124\u20103p in the endometrium and serum from women with CE and found an anticorrelation relationship between miR\u201027a\u20103p and IGF1 in endometrium. ROC curve analysis suggested that miRNA investigation in endometrium and serum could discriminate women with CE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MiR\u201027a\u20103p and miR\u2010124\u20103p could represent non\u2010invasive markers of CE and, in a near future, could be used to assess the endometrial quality in IVF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12858","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T04:35:22Z","timestamp":1523939722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["MiR\u201027a\u20103p and miR\u2010124\u20103p, upregulated in endometrium and serum from women affected by Chronic Endometritis, are new potential molecular markers of endometrial receptivity"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6036-4469","authenticated-orcid":false,"given":"Cinzia","family":"Di Pietro","sequence":"first","affiliation":[{"name":"Biology and Genetics Section Department of Biomedical and Biotechnological Sciences University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical Surgical Specialties University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Biology and Genetics Section Department of Biomedical and Biotechnological Sciences University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Iraci Sareri","sequence":"additional","affiliation":[{"name":"Department 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