{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:32:36Z","timestamp":1785299556389,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Problem<\/jats:title>To study the prevalence of HHV<\/jats:styled-content>\u20106 in endometrial biopsies among women experiencing recurrent implantation failure (RIF<\/jats:styled-content>) after IVF<\/jats:styled-content>\/ET<\/jats:styled-content> compared with controls.<\/jats:p><\/jats:sec>Method of Study<\/jats:title>Thirty women experiencing RIF<\/jats:styled-content> after IVF<\/jats:styled-content>\/ET<\/jats:styled-content> and 10 fertile women participated in the study. All women had endometrial biopsies taken in the luteal phase of their menstrual cycle for an endometrial immune profile (EIP<\/jats:styled-content>) and HHV<\/jats:styled-content>\u20106 mRNA<\/jats:styled-content> as well as lymphocyte and granulocyte populations. The prevalence of HHV<\/jats:styled-content>\u20106 in endometrial biopsies was determined, and biopsies for positive and negative expression of HHV<\/jats:styled-content>\u20106 were compared with the results of their EIP<\/jats:styled-content> and lymphocyte and granulocyte populations.<\/jats:p><\/jats:sec>Results<\/jats:title>Thirty\u2010seven percentage of women with a history of RIF<\/jats:styled-content> and 0% of controls demonstrated the presence of HHV<\/jats:styled-content>\u20106 in their endometrial biopsies. No associations were found when the results of the endometrial immune profile were compared with the presence or absence of HHV<\/jats:styled-content>\u20106. Significant increase in neutrophil\u2010specific CD<\/jats:styled-content>16b mRNA<\/jats:styled-content> was found in HHV<\/jats:styled-content>\u20106\u2010positive samples, and the levels of B cells\u2010related CD<\/jats:styled-content>19 mRNA<\/jats:styled-content> were lower in biopsies from women with RIF<\/jats:styled-content> in comparison with normal controls.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>HHV<\/jats:styled-content>\u20106 infection is an important factor in RIF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12862","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T04:41:24Z","timestamp":1524026484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prevalence of HHV<\/scp>\u20106 in endometrium from women with recurrent implantation failure"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5920-791X","authenticated-orcid":false,"given":"Carolyn B.","family":"Coulam","sequence":"first","affiliation":[{"name":"Reproductive Medicine Institute Evanston IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Bilal","sequence":"additional","affiliation":[{"name":"Department Microbiology and Immunology Clinical Immunology Laboratory Rosalind Franklin University of Medicine and Science North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Salazar Garcia","sequence":"additional","affiliation":[{"name":"Reproductive Medicine and Immunology Department of Obstetrics and Gynecology Chicago Medical School Rosalind Franklin University of Medicine and Science Vernon Hills IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimantha","family":"Katukurundage","sequence":"additional","affiliation":[{"name":"Department Microbiology and Immunology Clinical Immunology Laboratory Rosalind Franklin University of Medicine and Science North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidy","family":"Elazzamy","sequence":"additional","affiliation":[{"name":"Department Microbiology and Immunology Clinical Immunology Laboratory Rosalind Franklin University of Medicine and Science North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio F.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Clinic Las Condes Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kwak\u2010Kim","sequence":"additional","affiliation":[{"name":"Reproductive Medicine and Immunology Department of Obstetrics and Gynecology Chicago Medical School Rosalind Franklin University of Medicine and Science Vernon Hills IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Beaman","sequence":"additional","affiliation":[{"name":"Department Microbiology and Immunology Clinical Immunology Laboratory Rosalind Franklin University of Medicine and Science North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Dambaeva","sequence":"additional","affiliation":[{"name":"Department Microbiology and Immunology Clinical Immunology Laboratory Rosalind Franklin University of Medicine and Science North Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(08)60999-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.04.035"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.11.017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.04.017"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev140"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der164"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030305"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1452"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(89)90382-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003257"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158304"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-013-1902-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24561"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002951"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02758.x"},{"key":"e_1_2_5_17_1","first-page":"443","article-title":"No serological evidence for a role of HHV\u20106 infection in chronic fatigue syndrome","volume":"4","author":"Burbelo PD","year":"2012","journal-title":"Am J Transl Res"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12483"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12730"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905535106"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3181c9e7a1"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.56.5.559"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.09.025"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048810"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18881-2_5"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.12862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.12862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T04:21:20Z","timestamp":1695442880000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.12862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,17]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/aji.12862"],"URL":"https:\/\/doi.org\/10.1111\/aji.12862","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,17]]},"assertion":[{"value":"2018-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12862"}}