{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:11:02Z","timestamp":1771485062347,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T00:00:00Z","timestamp":1524614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["1285975"],"award-info":[{"award-number":["1285975"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007417","name":"Paulon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007417","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>What is the role of past <jats:italic>Chlamydia trachomatis<\/jats:italic> infection in unexplained infertility?<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>This is a prospective study of the impact of past <jats:italic>C.\u00a0trachomatis<\/jats:italic> infection on pregnancy rates in 96 women with unexplained infertility. Both humoral and cell\u2010mediated immune responses (<jats:styled-content style=\"fixed-case\">CMI<\/jats:styled-content>) against <jats:italic>C.\u00a0trachomatis<\/jats:italic> were studied. Serum <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG antibodies were analyzed using major outer membrane protein (<jats:styled-content style=\"fixed-case\">MOMP<\/jats:styled-content>) peptide\u2010based <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CMI<\/jats:styled-content> was studied by lymphocyte proliferation (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) assay in vitro. Data on given fertility treatment, time to pregnancy, and pregnancy outcome were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether, 11.5% of the 96 women had <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG antibodies. <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> response to <jats:italic>C.\u00a0trachomatis<\/jats:italic> was positive in 62.9% women. The overall pregnancy rate or live birth rate did not differ by the presence of antichlamydial antibodies or <jats:styled-content style=\"fixed-case\">CMI<\/jats:styled-content> against <jats:italic>C.\u00a0trachomatis<\/jats:italic>. Time to spontaneous pregnancy was longer among <jats:italic>C.\u00a0trachomatis<\/jats:italic> sero\u2010positive women than among sero\u2010negative women (2.9\u00a0years vs 2.0\u00a0years, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Past chlamydial infection does not play a major role in unexplained infertility. Women with unexplained infertility and positive immune response to <jats:italic>C.\u00a0trachomatis<\/jats:italic> do not have reduced pregnancy rates, but time to spontaneous pregnancy is longer among <jats:italic>C.\u00a0trachomatis<\/jats:italic> IgG sero\u2010positive women than among sero\u2010negative women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12865","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T10:12:31Z","timestamp":1524651151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Chlamydia trachomatis<\/i>\u2010induced cell\u2010mediated and humoral immune response in women with unexplained infertility"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0257-1256","authenticated-orcid":false,"given":"Tiina","family":"Rantsi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Helsinki University 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