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One hundred and seven <jats:styled-content style=\"fixed-case\">PTL<\/jats:styled-content> patients were selected and divided into a 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>\u2010C group (use of 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>\u2010C: n\u00a0=\u00a053) and a no\u2010treatment group (no use of 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>\u2010C: n\u00a0=\u00a054). Moreover, the patients were divided into three subgroups (subgroup A: without intra\u2010amniotic inflammation, B: with mild intra\u2010amniotic inflammation, and C: with severe intra\u2010amniotic inflammation) according to their level of amniotic interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20108, and perinatal prognosis was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Interval from admission to delivery (days) in the 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>\u2010C group (76 [13\u2010126], n\u00a0=\u00a034) was significantly longer than that in the no\u2010treatment group (50 [8\u2010104], n\u00a0=\u00a033; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) in subgroup B. In cases without intra\u2010amniotic microbes in subgroup B, a significant prolongation of gestational days was associated with the 17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>\u2010C group (79 [13\u2010126], n\u00a0=\u00a025) compared with the no\u2010treatment group (50 [8\u2010104], n\u00a0=\u00a029; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.029). However, there were no significant differences in subgroups A or C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>17<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>\u2010C could prolong gestational period in limited <jats:styled-content style=\"fixed-case\">PTL<\/jats:styled-content> cases with sterile mild intra\u2010amniotic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12867","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T17:51:44Z","timestamp":1525110704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["17<scp>OHP<\/scp>\u2010C in patients with spontaneous preterm labor and intact membranes: is there an effect according to the presence of intra\u2010amniotic inflammation?"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0861-3931","authenticated-orcid":false,"given":"Satoshi","family":"Yoneda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arihiro","family":"Shiozaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Ueno","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Niimi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Tamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center Toyama University Hospital  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center Toyama University Hospital  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Makimoto","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center Toyama University Hospital  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketoshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Maternal and Perinatal Center Toyama University Hospital  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8940-3708","authenticated-orcid":false,"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Toyama  Sugitani Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035140"},{"key":"e_1_2_6_3_1","unstructured":"FDA.FDA approves drug to reduce risk of preterm birth in at\u2010risk pregnancy women.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2011\/021945orig1s000crossr.pdf. 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