{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:00:53Z","timestamp":1792000853515,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>There is a paucity of research on the contribution of placental inflammation to severe retinopathy of prematurity (<jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>A retrospective cohort study (n\u00a0=\u00a01217) was conducted of infants screened for <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> (2006\u20102016). The outcomes of the study were severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> (type 1 or type 2 <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>) and low grade <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. We categorized the placental pathology as the presence of (i) maternal plus fetal inflammatory response, (ii) maternal inflammatory response only, (iii) fetal inflammatory response only and, (iv) no evidence of a maternal or fetal inflammatory response. The data were analyzed using univariate and multivariate logistic regression analyses (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this cohort, the number of infants with the maternal plus fetal inflammatory response, the maternal inflammatory response only, the fetal inflammatory response only, and no maternal or fetal inflammatory response was 305 (25%), 82 (7%), 8 (1%), and 822 (67%), respectively<jats:bold>.<\/jats:bold> Adjusted for covariates, the maternal plus fetal inflammatory response was a significant risk factor for severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a02.6, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20105.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). None of the categories of placental inflammation were significantly associated with low grade <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placental pathology distinguished by the maternal plus fetal inflammatory response was a significant risk factor for severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>. Our study supports a link between intrauterine inflammatory events and the subsequent development of severe <jats:styled-content style=\"fixed-case\">ROP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.12986","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T09:49:10Z","timestamp":1527155350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The role of the maternal and fetal inflammatory response in retinopathy of prematurity"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6508-8136","authenticated-orcid":false,"given":"Anne M.","family":"Lynch","sequence":"first","affiliation":[{"name":"Department of Ophthalmology University of Colorado School of Medicine  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber 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