{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:55:45Z","timestamp":1787054145329,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201502035"],"award-info":[{"award-number":["SZSM201502035"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Medical Research of Chinese Medical Association-Reproductive Medicine Clinical Research and Development Youth Program","award":["17020300699"],"award-info":[{"award-number":["17020300699"]}]},{"name":"Clinical Medical Research of Chinese Medical Association-Reproductive Medicine Clinical Research and Development Youth Program","award":["17020340703"],"award-info":[{"award-number":["17020340703"]}]},{"name":"Basic Research Program of Shenzhen","award":["JCYJ20170307140647669"],"award-info":[{"award-number":["JCYJ20170307140647669"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"\n Problem<\/jats:title>\n \n The role of\n ILT<\/jats:styled-content>\n 4\n +<\/jats:sup>\n DC<\/jats:styled-content>\n s in healthy fertile controls and patients with recurrent miscarriages (\n RM<\/jats:styled-content>\n ) and recurrent implantation failure (\n RIF<\/jats:styled-content>\n ) is unclear.\n <\/jats:p>\n <\/jats:sec>\n \n Method of study<\/jats:title>\n \n We studied the expression of\n ILT<\/jats:styled-content>\n 4 from peripheral blood and endometrial samples from healthy controls and patients with\n RM<\/jats:styled-content>\n and\n RIF<\/jats:styled-content>\n by flow cytometry and immunohistochemistry analysis. Endometrial Foxp3 expression was also investigated using immunohistochemistry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In peripheral blood, there was a significant increase in the percentage of\n ILT<\/jats:styled-content>\n 4\n +<\/jats:sup>\n DC<\/jats:styled-content>\n s in healthy fertile controls compared with patients with\n RM<\/jats:styled-content>\n and\n RIF<\/jats:styled-content>\n . The presence of\n ILT<\/jats:styled-content>\n 4\n +<\/jats:sup>\n DC<\/jats:styled-content>\n is even more prominent in the endometrium of healthy fertile controls compared with patients with\n RM<\/jats:styled-content>\n and\n RIF<\/jats:styled-content>\n . Moreover, there was a strong correlation between the number of\n ILT<\/jats:styled-content>\n 4\n +<\/jats:sup>\n cells and Foxp3\n +<\/jats:sup>\n Tregs in healthy fertile controls, but not in patients with\n RM<\/jats:styled-content>\n and\n RIF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our data indicate that\n ILT<\/jats:styled-content>\n 4\n +<\/jats:sup>\n DC<\/jats:styled-content>\n s play an important role in the maintenance of immune tolerance during pregnancy, probably through the induction of Foxp3\n +<\/jats:sup>\n Treg cells, a process which is impaired in\n RM<\/jats:styled-content>\n and\n RIF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aji.12998","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:10:59Z","timestamp":1529021459000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Downregulation of\n ILT<\/scp>\n 4\n +<\/sup>\n dendritic cells in recurrent miscarriage and recurrent implantation failure"],"prefix":"10.1111","volume":"80","author":[{"given":"Su","family":"Liu","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Reproductive Immunology for Peri\u2010implantation Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Fertility Center Shenzhen Zhongshan Urology Hospital Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Wei","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Reproductive Immunology for Peri\u2010implantation Shenzhen Zhongshan Institute for 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