{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:36:25Z","timestamp":1759941385668,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T00:00:00Z","timestamp":1531699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Capital special fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"Problem<\/jats:title>Evaluate the response rate of glucocorticoid (GC<\/jats:styled-content>) and\/or immunoglobulin (IVI<\/jats:styled-content>g) therapy in severe thrombocytopenia of immune thrombocytopenia (ITP<\/jats:styled-content>) pregnant patients and the influence on maternal and neonatal outcomes.<\/jats:p><\/jats:sec>Method of study<\/jats:title>This is a prospective observational cohort study. Pregnant ITP<\/jats:styled-content> patients with platelet count less than 30\u00a0\u00d7\u00a0109<\/jats:sup>\/L and their newborn infants participated in this research. Over a 3\u2010year period, 87 patients were allocated to 4 groups: group 1 (n\u00a0=\u00a018) were treated by oral prednisone, group 2 (n\u00a0=\u00a020) with IVI<\/jats:styled-content>g, group 3 (n\u00a0=\u00a022) with prednisone\/methlyprednisone plus IVI<\/jats:styled-content>g, and group 4 were non\u2010treatment controls (n\u00a0=\u00a027). Diagnosis and therapy were based on guideline from the 2011 American Society of Hematology criteria, and the initial dose of prednisone was 1\u00a0mg\/kg\u00a0day. Their newborns were followed up to 1\u00a0year old.<\/jats:p><\/jats:sec>Results<\/jats:title>The response rate among patients who ever received prednisone therapy was 35.5% (11\/31) overall, while the IVI<\/jats:styled-content>g response rate was 55.9% (19\/34). The incidence of pregnancy induced hypertension in GC<\/jats:styled-content> therapy group was significantly higher than controls (22.2% and 13.6% vs 0%). There was no significant difference in neonatal outcomes in treatment groups in comparison with controls. The rate of Neonatal follow\u2010up within 1\u00a0year old was 63%, and there is no evidence indicated intrauterine GC<\/jats:styled-content> exposure influence the growth and development.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>GC<\/jats:styled-content> therapy of 1\u00a0mg\/kg for ITP<\/jats:styled-content> patients during pregnancy is less efficiency than non\u2010pregnant population and increases the incidence of hypertensive disorders. The use of lower starting doses of prednisone may be suggested for use in pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13000","type":"journal-article","created":{"date-parts":[[2018,7,16]],"date-time":"2018-07-16T09:24:57Z","timestamp":1531733097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of glucocorticoid compared with immunoglobulin therapy of severe immune thrombocytopenia during pregnancy: Response rate and complication"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-6872","authenticated-orcid":false,"given":"Xue","family":"Xu","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010ying","family":"Liang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Dou","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010liu","family":"Wang","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hematology Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(00)90106-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-448944"},{"key":"e_1_2_9_5_1","first-page":"934","article-title":"Consensus report for the management of pregnancy with primary immune thrombocytopenia","volume":"55","author":"Miyakawa Y","year":"2014","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04131.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3317"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-710285"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38313.624352.8F"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982137"},{"key":"e_1_2_9_13_1","unstructured":"AnitaR RobertoS AndraH.Clinical practice guide on thrombocytopenia in pregnancy [S\/OL]. 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