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In a majority of cases, the cause remains unknown but there is increasing evidence that immunologic factors play an important role. Intravenous immunoglobulin (\n                    <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>\n                    g) therapy has been proposed to have immune modulatory effects and therefore been applicable for the treatment of patients with\n                    <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>\n                    . Although its efficacy is still controversial, several recent studies suggest that\n                    <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>\n                    g treatment may improve pregnancy outcomes.\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and their related cytokines play an important role in maternal\u2010fetal immune regulation, and an imbalance of Th17\/Treg cell ratio has been proposed as a cause for\n                    <jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>\n                    . We review the scientific evidence supporting a modulatory effect of\n                    <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>\n                    g on Th17\/Treg cell balance and discuss the potential mechanisms how\n                    <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>\n                    g might enhance Treg cells function. We propose that correction of Th17\/Treg cell dysregulation could be one of the mechanisms that can explain the positive therapeutic effects of\n                    <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>\n                    g therapy. Consequently, selecting patients with abnormal Th17\/Treg cell ratios could increase the success of\n                    <jats:styled-content style=\"fixed-case\">IVI<\/jats:styled-content>\n                    g therapy.\n                  <\/jats:p>","DOI":"10.1111\/aji.13018","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T03:38:21Z","timestamp":1531107501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Modulatory effect of intravenous immunoglobulin on Th17\/Treg cell balance in women with unexplained recurrent spontaneous abortion"],"prefix":"10.1111","volume":"80","author":[{"given":"Kahinho P.","family":"Muyayalo","sequence":"first","affiliation":[{"name":"Family Planning Research Institute Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology  Wuhan 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