{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:42:32Z","timestamp":1792172552779,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>\n                    The female reproductive tract has an active microbiome, and it is suggested that these microbes could influence the outcome of assisted reproductive technologies (\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    ). This systematic review aimed to assess the vaginal\/uterine microbiome, specifically with regard to improving the outcome of\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    . English peer\u2010reviewed journals were searched for studies investigating the vaginal\/uterine micriobiome and female reproductive tract, using\n                    <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>\n                    guidelines. Twenty\u2010six studies were included, 19 studying the vaginal and seven investigating the uterine microbiome. Studies using culture\u2010based technologies found an abnormal vaginal microbiome\n                    <jats:styled-content style=\"fixed-case\">AVM<\/jats:styled-content>\n                    was not associated with\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    outcome. However, studies using sequence\u2010based technologies found an abnormal vaginal microbiome had a negative effect on\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    . An abnormal uterine microbiome impacted ART outcome in all of the studies which used culture\u2010based methods and the most extensive of the two studies using metagenomic sequencing. This review has revealed a lack of translational data relating an abnormal vaginal\/uterine microbiome to\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    outcomes, with inconsistencies between the results of the different studies. Therefore the nature of the relationship between the vaginal\/uterine microbiome and fertility remains unknown. As we better characterize this relationship using modern metagenomic techniques, the potential to manipulate the female reproductive tract microbiome to improve\n                    <jats:styled-content style=\"fixed-case\">ART<\/jats:styled-content>\n                    could be a reality.\n                  <\/jats:p>","DOI":"10.1111\/aji.13037","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T12:31:09Z","timestamp":1534941069000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Investigating the effect of an abnormal cervico\u2010vaginal and endometrial microbiome on assisted reproductive technologies: A systematic review"],"prefix":"10.1111","volume":"80","author":[{"given":"Timothy","family":"Bracewell\u2010Milnes","sequence":"first","affiliation":[{"name":"Division of Surgery and Cancer Institute of Developmental Reproductive &amp; Developmental Biology Imperial College 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