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Linear regression examined associations between MeHg exposure and immune markers with and without adjustment for PUFA<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>In all models, as MeHg concentrations increased, the Th1:Th2 ratio, total Th1 and individual Th1 (IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20102, TNF<\/jats:styled-content>\u2010\u03b1) concentrations decreased. MeHg was not associated with total Th2 cytokines but was associated with a decrease in IL<\/jats:styled-content>\u20104 and IL<\/jats:styled-content>\u201010. MeHg was positively associated with TARC<\/jats:styled-content> and VEGF\u2010D<\/jats:styled-content> and negatively associated with CRP<\/jats:styled-content>. There was a significant interaction between MeHg and the n\u20106:n\u20103 ratio, with MeHg associated with a larger decrease in Th1:Th2 at higher n\u20106:n\u20103 PUFA<\/jats:styled-content> ratios. The n\u20103 PUFA<\/jats:styled-content> were associated with lower CRP<\/jats:styled-content>, IL<\/jats:styled-content>\u20104 and higher IFN<\/jats:styled-content>\u2010\u03b3. The n\u20106 PUFA<\/jats:styled-content> were associated with higher IL<\/jats:styled-content>\u20101\u03b2, IL<\/jats:styled-content>\u20102, TNF<\/jats:styled-content>\u2010\u03b1, IL<\/jats:styled-content>\u20104, IL<\/jats:styled-content>\u201010, CRP<\/jats:styled-content> and IL<\/jats:styled-content>\u20106.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Maternal MeHg was associated with markers of immune function at 28\u00a0weeks\u2019 gestation. A significant interaction between MeHg and the n\u20106:n\u20103 ratio on the Th1:Th2 ratio suggests that the n\u20103 PUFA<\/jats:styled-content> may mitigate any immunosuppressive associations of MeHg. The n\u20103 and n\u20106 PUFA<\/jats:styled-content> were associated with suppressive and stimulatory immune responses, respectively. 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