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While p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> is an <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\u2010response kinase, a precise functional role is unknown. Therefore, we conducted a systematic review of literature on p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> expression, activation, and function in reproductive tissues throughout pregnancy and parturition, published between January 1980 and August 2017, using four electronic databases (Web of Science, PubMed, Medline, and Co<jats:styled-content style=\"fixed-case\">CHRANE<\/jats:styled-content>). We identified 418 reports; 108 were selected for full\u2010text evaluation and 74 were included in final review. p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> was investigated using feto\u2010maternal primary or immortalized cells, tissue explants, and animal models. Western blot was most commonly used to report phosphorylated (active) p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>. Human placenta (27), chorioamniotic membranes (14), myometrium (13), decidua (8), and cervix (1) were the studied tissues. p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>'s functions were tissue and gestational age dependent. Isoform specificity was hardly reported. p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content> activity was induced by <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> or proinflammatory cytokines to promote cell signaling linked to cell fate, primed uterus, ripened cervix, and proinflammatory cytokine\/chemokine production. In 35\u00a0years, reports on p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>'s role during pregnancy and parturition are scarce and current literature is insufficient to provide a comprehensive description of p38 <jats:styled-content style=\"fixed-case\">MAPK<\/jats:styled-content>'s mechanistic role during pregnancy and parturition.<\/jats:p>","DOI":"10.1111\/aji.13047","type":"journal-article","created":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T08:30:17Z","timestamp":1536049817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Systematic review of p38 mitogen\u2010activated kinase and its functional role in reproductive tissues"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-1747","authenticated-orcid":false,"given":"Samantha","family":"Sheller\u2010Miller","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal 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