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Total <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> was isolated from the <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content> cells of the decidual tissue obtained from patients with induced abortion at about the 8th gestational week. The potential contribution of regulatory mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s to a genetic predisposition to <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> was characterized by comparison with healthy and fertile controls and bioinformatics analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analysis of the mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression profiles identified 50 mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s that were differentially expressed, including one down\u2010regulated and 49 up\u2010regulated mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in the <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> group. Mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010Gene\u2010Network, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">GO<\/jats:styled-content>\u2010Network and mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010Gene\u2010<jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content>\u2010Network were constructed. The key mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s, genes, <jats:styled-content style=\"fixed-case\">GO<\/jats:styled-content>s and core <jats:styled-content style=\"fixed-case\">TF<\/jats:styled-content>s in the network were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that a close relationship exists between the aberrant mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>. Furthermore, these findings support the notion that altered expression of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s may contribute to the clinical diagnosis of <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content> and the potential to develop novel strategies for therapeutic targets against <jats:styled-content style=\"fixed-case\">URSA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13052","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T13:36:31Z","timestamp":1539956191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genome\u2010wide identification of micro<scp>RNA<\/scp>s in decidual natural killer cells from patients with unexplained recurrent spontaneous 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