{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T17:36:21Z","timestamp":1772645781243,"version":"3.50.1"},"reference-count":124,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Intrauterine infusion of human chorionic gonadotropin (IUI\u2010hCG) has been proposed to improve the outcome of in vitro fertilization\u2010embryo transfer (IVF\u2010ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI\u2010hCG on IVF\u2010ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI\u2010hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI\u2010hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI\u2010hCG should be highlighted in the future.<\/jats:p>","DOI":"10.1111\/aji.13077","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T19:49:43Z","timestamp":1545940183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF\/ET cycle: The critical review"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-8468","authenticated-orcid":false,"given":"Tao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong SAR"},{"name":"Shenzhen Youshare Biotechnology Co. Ltd Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3719-6601","authenticated-orcid":false,"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Chiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong SAR"},{"name":"Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Hong Kong City Hong Kong"},{"name":"School of Biomedical Sciences The Chinese University of Hong Kong Hong Kong City Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin Chiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Faculty of Medicine The Chinese University of Hong Kong, Prince of Wales Hospital Shatin Hong Kong SAR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Kwak\u2010Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Chicago Medical School Rosalind Franklin University of Medicine and Science North Chicago Illinois"},{"name":"Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School Rosalind Franklin University of Medicine and Science Vernon Hills Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.06.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-200012000-00023"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex264"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92957-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.2002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu033"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.07.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-013-0144-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0379-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2013.03.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.09.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022996"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.05.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12701"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2016.11.006"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"1286","article-title":"Autologous platelet\u2010rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization","volume":"8","author":"Chang Y","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.09.044"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060515592903"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12459"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.09.037"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61618-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/4.suppl_1.87"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(85)80066-7"},{"issue":"4","key":"e_1_2_8_26_1","first-page":"1449","article-title":"Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period","volume":"80","author":"Sawai K","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der027"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046682"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.12.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.051805"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.12.015"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/359076a0"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12679"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh450"},{"issue":"1","key":"e_1_2_8_35_1","first-page":"10","article-title":"Molecular aspects of direct LH\/hCG effects on human endometrium\u2013lessons from intrauterine microdialysis in the human female in vivo","volume":"1","author":"Licht P","year":"2001","journal-title":"Reprod Biol"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2008.00647.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12471"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2543"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03240-5"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03226-0"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-6374(98)80318-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1995.1105"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.12.031"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0378(02)00043-8"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep011"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064829"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-116"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26088"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)02165-4"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-5885fje"},{"issue":"1","key":"e_1_2_8_51_1","first-page":"307","article-title":"Expression of functional human chorionic gonadotropin\/human luteinizing hormone receptor gene in human uterine arteries","volume":"79","author":"Toth P","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020642"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-213686"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12080"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.112.100370"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew080"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0832"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12500"},{"issue":"4","key":"e_1_2_8_59_1","first-page":"1641","article-title":"Localization of the expression of complement component 3 in the human endometrium by in situ hybridization","volume":"81","author":"Sayegh RA","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5452.498"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719113477486"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.9.2386"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.64"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1309"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2008.00595.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12766"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12483"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.09.010"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12693"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00279.x"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2012.01115.x"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803177"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.135541"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202698"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12618"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12837"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0407258"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00146"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.06.013"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1727"},{"issue":"12","key":"e_1_2_8_81_1","first-page":"3954","article-title":"Uterine DCs are crucial for decidua formation during embryo implantation in mice","volume":"118","author":"Plaks V","year":"2008","journal-title":"J Clin Investig"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0395"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev016"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0138"},{"issue":"1","key":"e_1_2_8_85_1","first-page":"13","article-title":"B152 anti\u2010hyperglycosylated human chorionic gonadotropin free beta\u2010subunit. A new, possible treatment for cancer","volume":"60","author":"Cole LA","year":"2015","journal-title":"J Reprod Med"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0286"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.05.009"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gar033"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.09.016"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.08.023"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1577"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.07.1127"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.05.002"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-184663"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.037"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00240-8"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gax015"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det055"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.164.3.956"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.083"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-017-0418-7"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00986.x"},{"issue":"10","key":"e_1_2_8_103_1","first-page":"1049","article-title":"Correction by CSF\u20101 of defects in the osteopetrotic op\/op mouse suggests local, developmental, and humoral requirements for this growth factor","volume":"19","author":"Wiktor\u2010Jedrzejczak W","year":"1991","journal-title":"Exp Hematol"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-9"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.08.006"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363235"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew236"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-015-0069-1"},{"issue":"1","key":"e_1_2_8_109_1","first-page":"1","article-title":"Intrauterine administration of recombinant human chorionic gonadotropin before embryo transfer on outcome of in vitro fertilization\/ intracytoplasmic sperm injection: a randomized clinical trial","volume":"12","author":"Zarei A","year":"2014","journal-title":"Iran J Reprod Med"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.14.10.657"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.199096"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4752-2"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2016.1207164"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12809"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.069575"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-1049-5"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.06.035"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmu027"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)00663-0"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00137-5"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah150"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530162100"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(03)00084-5"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-017-1088-y"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010287"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faji.13077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T11:08:08Z","timestamp":1694430488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":124,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/aji.13077"],"URL":"https:\/\/doi.org\/10.1111\/aji.13077","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,23]]},"assertion":[{"value":"2018-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13077"}}