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Accumulating studies have indicated that immune dysregulation is associated with the pathogenesis of the female reproductive system, which causes preeclampsia (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>), recurrent spontaneous abortion (<jats:styled-content style=\"fixed-case\">RSA<\/jats:styled-content>), ruptured ectopic pregnancy, and so on. And some studies have revealed the pleiotropic and essential role of efferocytosis in these obstetrical disorders. More specifically, the occurrence and development of these diseases were in connection with some efferocytosis\u2010related factors and signals, such as C1q, <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201033\/<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>2. In this review, we systematically review the diverse impacts of efferocytosis in immune system and discuss its relevance to normal and pathological pregnancy. These findings may instruct future basic researches as well as clinical applications of efferocytosis\u2010related factors and signals as latent predictors or therapeutic targets on the obstetrical disorders.<\/jats:p>","DOI":"10.1111\/aji.13088","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T02:47:10Z","timestamp":1546829230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Insights of efferocytosis in normal and pathological pregnancy"],"prefix":"10.1111","volume":"82","author":[{"given":"Yan\u2010Ran","family":"Sheng","sequence":"first","affiliation":[{"name":"Laboratory for Reproductive Immunology Hospital of Obstetrics and Gynecology Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Ting","family":"Hu","sequence":"additional","affiliation":[{"name":"Laboratory for Reproductive Immunology Hospital of Obstetrics and 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