{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T02:20:06Z","timestamp":1785205206295,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T00:00:00Z","timestamp":1550880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The lectin pathway of the complement system may be involved in the pathogenesis of pre\u2010eclampsia. We aimed to investigate changes in serum concentrations of a broad range of lectin pathway proteins during normal pregnancy and their association with pre\u2010eclampsia, placental infarctions and intrauterine growth restriction (IUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>We included 51 women with normotensive pregnancies and 54 women with pregnancies complicated by pre\u2010eclampsia. Blood samples were obtained at gestational weeks 16, 33, 37, and after delivery for the normotensive pregnant women and before and after delivery for women with pre\u2010eclampsia. Mannose\u2010binding lectin (MBL), H\u2010 and M\u2010ficolin, collectin liver\u20101 (CL\u2010L1), MBL\u2010associated serine protease (MASP)\u20101, MASP\u20102 and MASP\u20103 and MBL\u2010associated proteins of 19 (MAp19) and 44 (MAp44) kDa were analysed. Clinical information was obtained from medical records. The placentae were examined by two experienced perinatal pathologists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lectin pathway protein concentrations generally increased during normal pregnancy and decreased after delivery in both normotensive pregnant women and women with pre\u2010eclampsia. Exceptions were MASP\u20103 which increased after delivery in both groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and H\u2010ficolin which increased after delivery in pre\u2010eclampsia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). H\u2010ficolin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), M\u2010ficolin (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005) and MASP\u20103 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) concentrations were lower in women with pre\u2010eclampsia than in normotensive pregnant women. Low MASP\u20103 concentrations were associated with placental infarction (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and IUGR (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Low H\u2010ficolin concentrations were associated with IUGR (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In general, lectin pathway protein serum concentrations increased during normal pregnancy. H\u2010ficolin and MASP\u20103 may be involved in the pathophysiology of pre\u2010eclampsia and IUGR and could be potential future pre\u2010eclampsia biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13092","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T16:43:28Z","timestamp":1548348208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lectin pathway proteins of the complement system in normotensive pregnancy and pre\u2010eclampsia"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2978-5185","authenticated-orcid":false,"given":"Julie Brogaard","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita Sylvest","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Herlev University Hospital Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine Lodberg","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Rud","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Zealand University Hospital K\u00f8ge Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Mette","family":"Hvas","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette Tarp","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"issue":"5","key":"e_1_2_8_4_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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