{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:39:05Z","timestamp":1792550345905,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>The aim of this study was to investigate the prevalence of and the association between endometriosis, fibromyalgia, and autoimmune disease (AID) in a large population database and to describe healthcare resource utilization (HCRU) in affected women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cross\u2010sectional study was performed using the computerized databases of Maccabi Healthcare Services (MHS), a 2.1\u2010million\u2010member healthcare plan in Israel. Age\u2010sex\u2010specific point prevalence rates of endometriosis and fibromyalgia were calculated for end of 2015. Socio\u2010demographic characteristics, HCRU, co\u2010morbidities, including AID and depression or anxiety were described according to endometriosis\/fibromyalgia status and analyzed using ordinary logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among a total population of 781\u00a0571 adult women, 6647 were diagnosed with endometriosis (8.5 per 1000) and 25\u00a0425 with fibromyalgia (32 per 1000). A total of 401 women (0.5 per 1000) were diagnosed with both conditions. In 2015, the mean age of the women diagnosed with endometriosis and fibromyalgia was 42 and 55\u00a0years, respectively. Women with co\u2010occurrence were characterized by increased HCRU and a high prevalence rate of AID compared to women with no diagnosis of endometriosis\/fibromyalgia, with 6.2% diagnosed with inflammatory bowel disease (IBD) vs 1% in the comparison group. The prevalence of fibromyalgia in women with endometriosis was 6%. Adjusted ORs (95% CI) for fibromyalgia among endometriosis patients were 4.1 (2.02\u20108.36) for systemic lupus erythematosus (SLE), 3.1 (1.5\u20106.2) for Sj\u00f6gren syndrome, 2.9 (1.87\u20104.7) for IBD, 2.1 (1.6\u20102.7) for dispensed antidepressants, and 1.7 (1.37\u20102.2) for diagnosed anxiety\/depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Co\u2010occurrence of endometriosis and fibromyalgia is associated with a high burden of AID, anxiety\/depression, and HCRU.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13095","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T17:09:52Z","timestamp":1548436192000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Evidence for an association between endometriosis, fibromyalgia, and autoimmune diseases"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8270-8122","authenticated-orcid":false,"given":"Hila","family":"Greenbaum","sequence":"first","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Weil","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Maccabi Institute for Research and Innovation Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chodick","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Maccabi Institute for Research and Innovation Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varda","family":"Shalev","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Maccabi Institute for Research and Innovation Maccabi Healthcare Services Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-9957","authenticated-orcid":false,"given":"Vered H.","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Maccabi Institute for Research and Innovation Maccabi Healthcare Services Tel Aviv Israel"},{"name":"Department of Obstetrics and Gynecology Sheba Medical Centre Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh275"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.01.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002469"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108330568"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70302-8"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1083-3188(97)70085-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.01878.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.09.041"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14711"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"e_1_2_8_12_1","first-page":"39","article-title":"Prevalence of fibromyalgia in the Israeli population: a population\u2010based study to estimate the prevalence of fibromyalgia in the Israeli population using the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFESSQ)","volume":"30","author":"Ablin JN","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_13_1","first-page":"297","article-title":"Evidence of disordered symptom appraisal in fibromyalgia: increased rates of reported comorbidity and comorbidity severity","volume":"17","author":"Wolfe F","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00252.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.10.2715"},{"key":"e_1_2_8_16_1","unstructured":"CohenR.H. 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