{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:43Z","timestamp":1787242003589,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C0306"],"award-info":[{"award-number":["HI14C0306"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1A6A3A11932253"],"award-info":[{"award-number":["2016R1A6A3A11932253"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Abstract<\/jats:title>\n \n Problem<\/jats:title>\n \n The stability and dominance of\n Lactobacillus<\/jats:italic>\n spp. in vaginal fluid are important for reproductive health. However, the characterization of the vaginal microbiota of women with preterm labor (PTL) or preterm premature rupture of membranes (P\u2010PROM), and its association with preterm birth (PTB) are poorly understood.\n <\/jats:p>\n <\/jats:sec>\n \n Method of study<\/jats:title>\n \n We collected vaginal fluid from women at risk of PTB (n\u00a0=\u00a058) in five university hospitals in Korea. We performed a hierarchical clustering analysis and classification according to the\n Lactobacillus<\/jats:italic>\n spp. and\n Lactobacillus<\/jats:italic>\n abundance using Illumina MiSeq sequencing of 16S rRNA gene amplicons.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Women at risk for PTB caused by P\u2010PROM had greater bacterial richness and diversity at the time of admission than those with PTL (\n P<\/jats:italic>\n \u00a0<\u00a00.05). However, they were not significantly different between term and preterm samples. In the classification by\n Lactobacillus<\/jats:italic>\n spp., the community commonly dominated by\n Bacteroides<\/jats:italic>\n and\n Lactobacillus crispatus<\/jats:italic>\n was found for the first time in pregnant women in Korea, and all women with this community delivered preterm. Intriguingly, women with an abundance of\n Weissella<\/jats:italic>\n in a\n Bacteroides<\/jats:italic>\n \u2010dominant community delivered at term. Moreover, in the classification by\n Lactobacillus<\/jats:italic>\n proportion, the abundances of\n Weissella<\/jats:italic>\n and\n Rickettsiales<\/jats:italic>\n were associated with term deliveries, but the abundances of\n Bacteroides<\/jats:italic>\n and\n Escherichia\u2010Shigella<\/jats:italic>\n were associated with PTBs (\n P<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This result suggests that\n Lactobacillus<\/jats:italic>\n abundance\u2010based classification of vaginal fluid may reveal the microbiome associated with PTB. Further studies are needed to investigate the mechanism underlying the link between the microbiome and PTB.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aji.13124","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:18:30Z","timestamp":1559002710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Vaginal microbiome profiles of pregnant women in Korea using a 16S metagenomics approach"],"prefix":"10.1111","volume":"82","author":[{"given":"Young\u2010Ah","family":"You","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology and Ewha Medical Research Institute, College of Medicine Ewha Womans University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology and Ewha Medical Research Institute, College of Medicine Ewha Womans University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk\u2010Joo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Sung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Konkuk University Medical Center Konkuk University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae\u2010Kyung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul 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