{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:14:17Z","timestamp":1789996457168,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1D1A1B03931905"],"award-info":[{"award-number":["2016R1D1A1B03931905"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Maternal inflammation leads to preterm birth and perinatal brain injury. Melatonin, through its anti\u2010inflammatory effects, has been shown to be protective against inflammation\u2010induced perinatal adverse effects. However, the immunomodulatory effects of melatonin on preterm birth and prematurity\u2010related morbidity remain unknown. We wanted to investigate the effects of maternally administered melatonin on preterm birth and perinatal brain injury in a mouse model of maternal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>A model of maternal inflammation employing lipopolysaccharide (LPS) was used to mimic the most common clinical scenario of preterm birth, that of maternal inflammation. Mice were randomly divided into the following groups: control, LPS, and LPS with melatonin pre\u2010treatment. Doppler ultrasonography was used to obtain fetal and maternal hemodynamic measurements in utero. Placenta and fetal brains were harvested and analyzed for proinflammatory markers and signs of perinatal brain injury, respectively. Surviving offspring were assessed for neuromotor outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Melatonin pre\u2010treatment lowered the level of proinflammatory cytokines in the uterus and the placenta, significantly improved LPS\u2010induced acute fetal neuroinflammation and perinatal brain injury, as well as significantly upregulated the SIRT1\/Nrf2 signaling pathway to reduce LPS\u2010induced inflammation. Melatonin also prevented adverse neuromotor outcomes in offspring exposed to maternal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternally administered melatonin modulated immune responses to maternal inflammation and decreased preterm birth and perinatal brain injury. These results suggest that melatonin, a safe treatment during pregnancy, may be used as an experimental therapeutic in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13151","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T05:58:40Z","timestamp":1558936720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Administration of melatonin for prevention of preterm birth and fetal brain injury associated with premature birth in a mouse model"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-0245","authenticated-orcid":false,"given":"Ji Yeon","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University School of Medicine Seongnam Korea"},{"name":"Department of Gynecology and Obstetrics Integrated Research Center for Fetal Medicine Johns Hopkins University School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haengseok","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Life Science CHA University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyunbileg","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University School of Medicine Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, College of Life Science CHA University Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na E.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Integrated Research Center for Fetal Medicine Johns 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