{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:29:10Z","timestamp":1789946950921,"version":"4.0.1"},"reference-count":174,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275201300006C"],"award-info":[{"award-number":["HHSN275201300006C"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Pyroptosis, inflammatory programmed cell death, is initiated through the inflammasome and relies on the pore\u2010forming actions of the effector molecule gasdermin D. Herein, we investigated whether gasdermin D is detectable in women with spontaneous preterm labor and sterile intra\u2010amniotic inflammation or intra\u2010amniotic infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Amniotic fluid samples (n\u00a0=\u00a0124) from women with spontaneous preterm labor were subdivided into the following groups: (a) those who delivered at term (n\u00a0=\u00a032); and those who delivered preterm (b) without intra\u2010amniotic inflammation (n\u00a0=\u00a041), (c) with sterile intra\u2010amniotic inflammation (n\u00a0=\u00a032), or (d) with intra\u2010amniotic infection (n\u00a0=\u00a019), based on amniotic fluid IL\u20106 concentrations and the microbiological status of amniotic fluid (culture and PCR\/ESI\u2010MS). Gasdermin D concentrations were measured using an ELISA kit. Multiplex immunofluorescence staining was also performed to determine the expression of gasdermin D, caspase\u20101, and interleukin\u20101\u03b2 in the chorioamniotic membranes. Flow cytometry was used to detect pyroptosis (active caspase\u20101) in decidual cells from women with preterm labor and birth. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(a) Gasdermin D was detected in the amniotic fluid and chorioamniotic membranes from women who underwent spontaneous preterm labor\/birth with either sterile intra\u2010amniotic inflammation or intra\u2010amniotic infection, but was rarely detected in those without intra\u2010amniotic inflammation. (b) Amniotic fluid concentrations of gasdermin D were higher in women with intra\u2010amniotic infection than in those with sterile intra\u2010amniotic inflammation, and its expression in the chorioamniotic membranes was associated with caspase\u20101 and IL\u20101\u03b2 (inflammasome mediators). (c) Decidual stromal cells and leukocytes isolated from women with preterm labor and birth are capable of undergoing pyroptosis given their expression of active caspase\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pyroptosis can occur in the context of sterile intra\u2010amniotic inflammation and intra\u2010amniotic infection in patients with spontaneous preterm labor and birth<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13184","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T22:41:31Z","timestamp":1567032091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra\u2010amniotic inflammation or intra\u2010amniotic infection"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-5262","authenticated-orcid":false,"given":"Nardhy","family":"Gomez\u2010Lopez","sequence":"first","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Immunology, Microbiology and Biochemistry Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-5121","authenticated-orcid":false,"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology University of Michigan Ann Arbor MI USA"},{"name":"Department of Epidemiology and Biostatistics Michigan State University East Lansing MI USA"},{"name":"Center for Molecular Medicine and Genetics Wayne State University Detroit MI USA"},{"name":"Detroit Medical Center Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1712-7588","authenticated-orcid":false,"given":"Adi L.","family":"Tarca","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Computer Science Wayne State University College of Engineering Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Miller","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Panaitescu","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Schwenkel","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dereje W.","family":"Gudicha","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Physiology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Percy","family":"Pacora","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Jung","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaur\u2010Dong","family":"Hsu","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch Division of Obstetrics and Maternal\u2010Fetal Medicine Division of Intramural Research <i>Eunice Kennedy Shriver<\/i> National Institute of Child Health and Human Development National Institutes of Health U. S. Department of Health and Human Services Detroit MI USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University School of Medicine Detroit MI USA"},{"name":"Department of Physiology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61698-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.01.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb21771.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199805000-00011"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2003.00021.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904308"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"262","article-title":"Infection in the pathogenesis of preterm labor","volume":"12","author":"Romero R","year":"1988","journal-title":"Semin Perinatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90503-0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/107155769600300304"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70347-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70227-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod67.4.1337"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.70"},{"issue":"4","key":"e_1_2_8_18_1","first-page":"349","article-title":"Role of cytokines in preterm labor and birth","volume":"57","author":"Park JS","year":"2005","journal-title":"Minerva Ginecol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.11.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2007.tb00362.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0016"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028972"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw408"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12189"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12296"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.954243"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.11.032"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.958463"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2005.06.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00579.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.08.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90172-5"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1992.tb00737.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPM.2007.101"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802054550"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.591460"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.599083"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90450-6"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(12)80035-4"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12443"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy264"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802212109"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301604"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.116.144139"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116687656"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700870"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13049"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy261"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12825"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.009"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/iox180"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.07.049"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.08.002"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1997"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40599"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1703"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902425"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940180"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01046.x"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100229"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01050.x"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2011.01.003"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2231"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229010"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2257"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3452"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.007"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"issue":"10","key":"e_1_2_8_71_1","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1016\/S0021-9258(18)83546-3","article-title":"A pre\u2010aspartate\u2010specific protease from human leukocytes that cleaves pro\u2010interleukin\u20101 beta","volume":"264","author":"Black RA","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5227"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/356768a0"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1373520"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.206"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/386619a0"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08307.x"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020506300324"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)01936-3"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2070"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01044.x"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.216"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695415"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694696"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2017.01.003"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.10.004"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18629"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003056"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.078"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.076"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00830.x"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117680"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12685"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.09.013"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.018"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.03.017"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1416083"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1533947"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13031"},{"issue":"4","key":"e_1_2_8_103_1","first-page":"260","article-title":"A proposal for a new method of evaluation of the newborn infant","volume":"32","author":"Apgar V","year":"1953","journal-title":"Curr Res Anesth Analg"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2016.1256985"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1315666"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.040"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.056"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2018-0055"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90423-O"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(90)91106-M"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90503-0"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114583"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-7070-y"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031819"},{"key":"e_1_2_8_115_1","first-page":"e52863","article-title":"Isolation of leukocytes from the human maternal\u2010fetal interface","volume":"99","author":"Xu Y","year":"2015","journal-title":"J Vis Exp"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29645"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2017-0393OC"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12827"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13171"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90014-A"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1994.tb01115.x"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12723"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116678690"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007519"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747404"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.027"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6676"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6689"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.S091280"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12617"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.1907-1916.2005"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.013"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1121-9"},{"issue":"2","key":"e_1_2_8_134_1","first-page":"118","article-title":"Antenatal estimation of fetal maturity by exfoliative cytology of amniotic fluid (author's transl)","volume":"183","author":"Agorastos T","year":"1979","journal-title":"Z Geburtshilfe Perinatol"},{"issue":"3","key":"e_1_2_8_135_1","first-page":"178","article-title":"\"Ultrastructural aspects of amniotic\u2010fluid cells\". A. Non\u2010vital cells. II. Keratinocytes (author's transl)","volume":"185","author":"Agorastos T","year":"1981","journal-title":"Z Geburtshilfe Perinatol"},{"issue":"4","key":"e_1_2_8_136_1","first-page":"393","article-title":"Rapid identification of glial cells in human amniotic fluid with indirect immunofluorescence","volume":"28","author":"Koskull H","year":"1984","journal-title":"Acta Cytol"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a071847"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12398465"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.482"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147118"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12940"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.08.011"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02297-15"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0234"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-195902030-00010"},{"key":"e_1_2_8_146_1","first-page":"17","article-title":"Pathology of the placenta and cord in ascending and in haematogenous infection","volume":"77","author":"Blanc WA","year":"1979","journal-title":"Ciba Found Symp"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810133191503"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90447-Y"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91609-E"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2003.09.005"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12623"},{"issue":"4","key":"e_1_2_8_152_1","first-page":"275","article-title":"Activation of murine macrophages and lymphocytes by Ureaplasma diversum","volume":"58","author":"Chelmonska\u2010Soyta A","year":"1994","journal-title":"Can J Vet Res"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12117"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12225"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00548-17"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.1.1"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(89)90409-2"},{"issue":"1","key":"e_1_2_8_158_1","first-page":"19","article-title":"The effect of ATP on Ca(2+)\u2010dependent K+ channels of human red cells","volume":"43","author":"Romero PJ","year":"1992","journal-title":"Acta Cient Venez"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1140734"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12456"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.02.035"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1384460"},{"key":"e_1_2_8_163_1","first-page":"1","volume-title":"Cervix in Pregnancy and Labour","author":"Liggins CG","year":"1981"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-7-S1-S7"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023143"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.05.027"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.09.003"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1610740"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08938"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062148"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.40"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913490575"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310297"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91075"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305282"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T23:03:54Z","timestamp":1694214234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":174,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/aji.13184"],"URL":"https:\/\/doi.org\/10.1111\/aji.13184","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"2019-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13184"}}