{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:23:59Z","timestamp":1789626239277,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["94\u201003\u201030\u201029803"],"award-info":[{"award-number":["94\u201003\u201030\u201029803"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is associated with endoplasmic reticulum (ER) stress and pro\u2010inflammatory condition. The aim of the present study was to evaluate the effect of resveratrol treatment on pro\u2010inflammatory and ER stress markers in patients with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>\n                      Cumulus cells were obtained from 40 patients with PCOS who were divided into two groups: placebo and resveratrol treatment (receiving 800\u00a0mg\/d for 40\u00a0days) groups. Blood samples were obtained from all patients before and after the procedure to evaluate interleukin (IL)\u20106, IL\u20101\u03b2, IL\u201018, TNF\u2010\u03b1, NF\u2010\u03baB, and C\u2010reactive protein (CRP). Total RNA was extracted from cumulus cells, and cDNA was synthesized by reverse transcription. Expressions of five genes in ER stress response pathway (ATF4, ATF6, CHOP, GRP78, and XBP1s) were assessed with quantitative real\u2010time PCR. Statistical analysis was performed with Student's\n                      <jats:italic>t<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After treatment with resveratrol, it was found that serum levels of IL\u20106, IL\u20101\u03b2, TNF\u2010\u03b1, IL\u201018, NF\u2010\u03baB, and CRP decreased in the treatment group. In addition, gene expression results showed that the expression levels of ATF4 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and ATF6 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) significantly increased in the resveratrol treatment group, while the expression levels of CHOP, GRP78, and XBP1 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001 for all) significantly decreased.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results demonstrated that resveratrol has anti\u2010inflammatory effects through the suppression of NF\u2010\u03baB and NF\u2010\u03baB\u2013regulated gene products. On the other hand, resveratrol can modulate ER stress in granulosa cells (GCs) by altering the expression of genes involved in unfolding protein response (UPR) process. Our findings suggest that ER stress is a potential therapeutic target for patients with PCOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13186","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T16:48:16Z","timestamp":1567615696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Resveratrol treatment in patients with polycystic ovary syndrome decreased pro\u2010inflammatory and endoplasmic reticulum stress markers"],"prefix":"10.1111","volume":"83","author":[{"given":"Samaneh","family":"Brenjian","sequence":"first","affiliation":[{"name":"Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Moini","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics School of Medicine Tehran University of Medical Science 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