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The objective of this study was to assess changes in plasma cytokines associated with uncomplicated pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>To examine these changes, plasma levels of immune response mediators from healthy gravidas (N\u00a0=\u00a0115, gestation weeks 23\u201030) were compared with those from healthy non\u2010pregnant women (N\u00a0=\u00a042). Comparisons were performed using multiplex analysis for Th1 activity\u2010related cytokines (IFN\u2010\u03b3, IL\u20102, sIL\u20102R\u03b1, IL\u201012[P70], and IL\u201027), Th2 activity\u2010related cytokines (IL\u20104, IL\u20105, and IL\u201013), other immune response mediators (GM\u2010CSF, IL\u20101\u03b2, sIL\u20101RI, IL\u20106, IL\u20108, IL\u201015, IL\u201017A, IL\u201017F, IL\u201021, IL\u201022, IL\u201023, TGF\u03b21, TGF\u03b22, TGF\u03b23, and TNF\u03b1), regulatory T cell\u2013related cytokines (IL\u201010 and sTNFRII), adipokines (adiponectin, leptin, PAI\u20101, and resistin), chemokines (IP\u201010, MCP\u20101, and MIP\u20101\u03b2), and hematopoietic growth factor IL\u20107.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate linear regression models showed increased levels of IL\u20107, Th1\u2010, and Treg activity\u2010related cytokines and decreased levels of adipokines and chemokines in healthy gravidas compared with healthy non\u2010pregnant women. Additionally, season of the year, age, pre\u2010pregnancy body mass index, and HLA\u2010DR\/DQ genotypes for type 1 diabetes risk showed different and sometimes reciprocal influence on cytokine levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study stresses the importance of profiling immune response mediators during pregnancy to better understand the effect of healthy pregnancy on cytokine levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13188","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T16:54:10Z","timestamp":1567702450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Interleukin\u20107, T helper 1, and regulatory T\u2010cell activity\u2010related cytokines are increased during the second trimester of healthy pregnancy compared to non\u2010pregnant 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