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The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%\u20104% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti\u2010thyroid autoantibodies, antinuclear, anti\u2010transglutaminase, and anti\u2010endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role.<\/jats:p>","DOI":"10.1111\/aji.13200","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T14:37:19Z","timestamp":1571668639000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The pathogenic role of autoantibodies in recurrent pregnancy loss"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6160-0558","authenticated-orcid":false,"given":"Silvia","family":"D'Ippolito","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica U.O.C. di Ostetricia e Patologia Ostetrica Fondazione Policlinico Universitario A. 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