{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:40:08Z","timestamp":1780918808530,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,24]],"date-time":"2019-11-24T00:00:00Z","timestamp":1574553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Which is the prevalence and seroprevalence of celiac disease (CD) in women with recurrent reproductive failure?<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Retrospective study performed in a single infertility clinic from September 2016 to December 2017. A total of 690 women with unexplained history of recurrent miscarriage and\/or recurrent implantation failure were consecutively recruited. IgA anti\u2010transglutaminase 2 (TG2) antibody data were collected, as well as IgG anti\u2010TG2 and IgA\/IgG anti\u2010deamidated gluten peptide (DGP) data in most cases, and IgG anti\u2010gliadin antibodies occasionally. In selected women, HLA\u2010DQ genotyping was requested. Biopsy was suggested to all women with positive serological results or belonging to CD risk groups. Reproductive outcomes were recorded from women with high suspicion of CD and a control group comprised of 49 women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010TG2\u2013positive women comprised 1% of the sample. An additional 4% was observed considering less\u2010specific antibodies (31 women). Only 39% of sero\u2010positive women accepted duodenal biopsy. HLA and biopsy data discarded CD in 14 sero\u2010positive cases (37%), only one with anti\u2010TG2 antibodies. CD was suggested in 10 sero\u2010positive and three sero\u2010negative women (1.9%). Compared with controls, the live birthrate of the studied women with probable CD was significantly decreased before gluten removal of the diet (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.015), but significantly increased after that (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.020).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>One percent CD prevalence should be expected after anti\u2010TG2 serological screening. However, more sensitive approaches should be explored, especially considering the potential beneficial effect of the gluten\u2010free diet on the reproductive outcomes of women with CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13209","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T05:59:01Z","timestamp":1573451941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Exploring undiagnosed celiac disease in women with recurrent reproductive failure: The gluten\u2010free diet could improve reproductive outcomes"],"prefix":"10.1111","volume":"83","author":[{"given":"Diana","family":"Alecsandru","sequence":"first","affiliation":[{"name":"Unidad de Inmunolog\u00eda y Unidad de Endocrinolog\u00eda Reproductiva e Infertilidad Instituto Valenciano de Infertilidad Madrid IVIRMA Madrid 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