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This review compares the efficacy of a few treatment interventions (low\u2010dose aspirin (LDA), aspirin plus low molecular weight heparin (LMWH), or unfractionated heparin (UFH)) in preventing complications during pregnancy and miscarriages for women with RPL and APS, and the potential differences in therapeutic effects of UFH and LMWH when combined with aspirin. We searched randomized controlled trials (RCTs) in MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials and performed a systematic review and a Bayesian network meta\u2010analysis (NMA). Finally, we found aspirin alone had a lower live birth rate compared to LMWH plus aspirin (OR\u00a0=\u00a00.37; 95% CrI, 0.17, 0.71), and UFH plus aspirin showed a higher live birth rate than aspirin alone (OR\u00a0=\u00a02.63; 95% CrI, 1.04, 5.39) in NMA, treating with UFH plus aspirin or LMWH plus aspirin did not have difference on live birth. Furthermore, LDA alone resulted in a lower birthweight compared to heparin plus aspirin, while higher birthweight was found when compared UFH plus aspirin to LMWH plus aspirin (MD\u00a0=\u00a0895.40; 95% CrI, 817.40, 988.57) in NMA. Additionally, in women with RPL and APS and without a prior thrombosis, heparin plus aspirin improved birthweight but could not promote live birth rate compared to aspirin alone. In conclusion, heparin plus aspirin is recommended for women with RPL and APS. Notably UFH plus aspirin demonstrates the most significant therapeutic efficacy among these interventions in improving birthweight.<\/jats:p>","DOI":"10.1111\/aji.13219","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T02:31:13Z","timestamp":1577154673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparison of therapeutic interventions for recurrent pregnancy loss in association with antiphospholipid syndrome: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"83","author":[{"given":"Xiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics West China Second University Hospital Sichuan University Chengdu China"},{"name":"West China School of Medicine Sichuan University Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Thyroid &amp; Parathyroid Surgery West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Dawen","family":"Yu","sequence":"additional","affiliation":[{"name":"MOHH Holdings Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang","family":"Xiang","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Meng","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai fan","family":"Niu","sequence":"additional","affiliation":[{"name":"West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-0123","authenticated-orcid":false,"given":"Huili","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics West China Second University Hospital Sichuan University Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoy004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"key":"e_1_2_7_4_1","unstructured":"Royal College of Obstetricians and Gynaecologists.RCOG Green\u2010top Guideline No. 17: The Investigation and Treatment of Couples with Recurrent First\u2010trimester and Second\u2010trimester Miscarriage. 2011 1\u201018.https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/gtg_17.pdf. 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