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The objective of this article is to assess the current state of evidence available in the literature on intrauterine perfusion immunotherapies in women undergoing ART treatments. By considering the guidelines of Preferred Reporting Items for Systematic Reviews and Meta\u2010Analysis (PRISMA), the authors performed systematic review by searching the databases of PubMed\/MEDLINE and Scopus using the following key words: \u201crecurrent implantation failure,\u201d \u201cintrauterine infusion,\u201d \u201cPlatelet\u2010Rich Plasma (PRP),\u201d \u201cPeripheral Blood Mononuclear Cells (PBMC),\u201d \u201cGranulocyte Colony\u2010Stimulating Factor (G\u2010CSF),\u201d and \u201cHuman Chorionic Gonadotropin (hCG).\u201d The authors analyzed the indications and the impact of new immunological therapies with intrauterine infusions on the pregnancy outcomes of patients undergoing ART. PRP, PBMC, G\u2010CSF, and hCG were the four most used immunological therapies with intrauterine infusion. These new therapies appear to improve the results of ART treatments in cases of RIF. However, the small number of studies does not allow definitive conclusions about the effectiveness of these therapies.<\/jats:p>","DOI":"10.1111\/aji.13242","type":"journal-article","created":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T13:49:56Z","timestamp":1586094596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Intrauterine perfusion immunotherapies in recurrent implantation failures: Systematic review"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9943-9731","authenticated-orcid":false,"given":"Marcelo Borges","family":"Cavalcante","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Fortaleza University (UNIFOR) Fortaleza\u2010CE Brazil"},{"name":"CONCEPTUS \u2013 Reproductive Medicine Fortaleza\u2010CE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candice Torres de Melo 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