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Pre\u2010eclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in pre\u2010eclampsia is centered around abnormal placentation, inadequate spiral\u2010artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and\/or inflammatory mediators into maternal circulation triggering the systemic manifestations of pre\u2010eclampsia. ER stress, resulting in impaired autophagy and placental release of aggregated proteins, may also confer systemic stress to maternal organs in pre\u2010eclampsia. Extracellular vesicles (EVs), lipid\u2010bilayer enclosed structures containing macromolecules including proteins, miRNA, and other important nucleotides, have been suggested to play an important role in this maternal\u2010fetal communication. Circulating EVs are present in greater quantity in the plasma of pre\u2010eclampsia subjects compared to normal pregnancy, and the placental derived EVs have been shown to have altered protein and RNA cargo. In this review, we will focus on EVs and their role in pre\u2010eclampsia, specifically their role in immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.<\/jats:p>","DOI":"10.1111\/aji.13297","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T15:45:42Z","timestamp":1593791142000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Placental extracellular vesicles and pre\u2010eclampsia"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3488-556X","authenticated-orcid":false,"given":"Jessica","family":"Schuster","sequence":"first","affiliation":[{"name":"Department of Pediatrics Women and Infants Hospital of Rhode Island Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-6234","authenticated-orcid":false,"given":"Shi\u2010Bin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Infants Hospital of Rhode Island Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Padbury","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Infants Hospital of Rhode Island Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-3467","authenticated-orcid":false,"given":"Surendra","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Infants Hospital of Rhode Island Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.3.203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6564"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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