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As IVF technology improved, the number of multiple pregnancies increased, which led to gradual reduction in the number of embryos that were transferred. Embryo freezing (vitrification) was recommended to allow subsequent transfer if the fresh cycle was unsuccessful. However, experimentation has continued to improve pregnancy outcomes. We discuss here the significance of frozen embryo transfer cycle and the impact of uterine and peripheral immunity dominated by NK cells and regulatory T cells and human chorionic gonadotropin on pregnancy outcome in this innovative mode of IVF therapy.<\/jats:p>","DOI":"10.1111\/aji.13300","type":"journal-article","created":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T07:24:02Z","timestamp":1594538642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Novel predictive and therapeutic options for better pregnancy outcome in frozen embryo transfer cycles"],"prefix":"10.1111","volume":"85","author":[{"suffix":"III","given":"Warren J.","family":"Huber","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology LSUHSC School of Medicine and The Fertility Institute  New Orleans LA 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