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Pregnant women are considered to have a higher risk of severe morbidity and even mortality due to their susceptibility to respiratory pathogens and their particular immunologic state. Several studies assessing SARS\u2010CoV\u20102 infection during pregnancy reported adverse pregnancy outcomes in patients with severe conditions, including spontaneous abortion, preterm labor, fetal distress, cesarean section, preterm birth, neonatal asphyxia, neonatal pneumonia, stillbirth, and neonatal death. However, whether these complications are causally related to SARS\u2010CoV\u20102 infection is not clear. Here, we reviewed the scientific evidence supporting the contributing role of Treg\/Th17 cell imbalance in the uncontrolled systemic inflammation characterizing severe cases of COVID\u201019. Based on the recognized harmful effects of these CD4<jats:sup>+<\/jats:sup> T\u2010cell subset imbalances in pregnancy, we speculated that SARS\u2010CoV\u20102 infection might lead to adverse pregnancy outcomes through the deregulation of otherwise tightly regulated Treg\/Th17 ratios, and to subsequent uncontrolled systemic inflammation. Moreover, we discuss the possibility of vertical transmission of COVID\u201019 from infected mothers to their infants, which could also explain adverse perinatal outcomes. Rigorous monitoring of pregnancies and appropriate measures should be taken to prevent and treat early eventual maternal and perinatal complications.<\/jats:p>","DOI":"10.1111\/aji.13304","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T08:56:16Z","timestamp":1594716976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["COVID\u201019 and Treg\/Th17 imbalance: Potential relationship to pregnancy outcomes"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7055-4138","authenticated-orcid":false,"given":"Kahinho P.","family":"Muyayalo","sequence":"first","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"Department of Obstetrics and Gynecology University of Kinshasa Kinshasa Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Jia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maternal and Child Health Hospital of Hubei Province Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Mor","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China"},{"name":"C.S. Mott Center for Human Growth and Development Wayne State University School of Medicine Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-8315","authenticated-orcid":false,"given":"Ai\u2010Hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Health Center for Reproductive Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Severe acute respiratory syndrome\u2010related coronavirus: the species and its viruses \u2013 a statement of the Coronavirus Study Group","volume":"2020","author":"Gorbalenya AE","year":"2020","journal-title":"bioRxiv"},{"key":"e_1_2_9_3_1","unstructured":"Worldometer.COVID\u201019 coronavirus pandemic.2020;https:\/\/www.worldometers.info\/coronavirus. 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