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The versatility of molecular biology allows it to be effective in several medical fields that include reproduction, immunogenetics, and virology. Implementation of molecular and sequencing technology in reproductive medicine can add another layer of understanding to better define the causes behind infertility and recurrent reproductive loss. In the following, we examine current molecular methods for probing factors behind reproductive pregnancy loss including reverse transcription polymerase chain reaction and next generation sequencing (NGS). We review several current and potential genetic (DNA) and transcriptional (RNA)\u2010based parameters in women with infertility that can be significant in diagnosis and treatment. These molecular factors can be inferred either from genomic DNA or RNA locally within the endometrium. Furthermore, we consider infection\u2010based abnormalities such as human herpesvirus\u20106 and severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102). Finally, we present future directions as well as data demonstrating the potential role of human endogenous retroviruses in pregnancy loss. We hope these discussions will assist the clinician in delineating some of the intricate molecular factors that can contribute to infertility and recurrent reproductive failures.<\/jats:p>","DOI":"10.1111\/aji.13313","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T12:14:31Z","timestamp":1595679271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical molecular genetics evaluation in women with reproductive failures"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7370-0329","authenticated-orcid":false,"given":"Mahmood Y.","family":"Bilal","sequence":"first","affiliation":[{"name":"Clinical Immunology Laboratory Rosalind Franklin University of Medicine and Science North Chicago IL USA"},{"name":"Department of Microbiology and Immunology Chicago Medical School Rosalind Franklin University of Medicine and Science North Chicago IL 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