{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:52:00Z","timestamp":1790139120242,"version":"4.0.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Our study aims to investigate whether the anti\u2010thyroperoxidase antibody (TPO\u2010Ab) and TSH level in euthyroid women have any association with reproductive outcomes after the ART cycle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods of study<\/jats:title><jats:p>A total of 1107 patients who were enrolled in the study were divided into four groups based on serum TSH level and TPO\u2010Ab status: group A, 0.3\u00a0\u2264\u00a0TSH\u00a0&lt;\u00a02.5\u00a0mIU\/L and TPO\u2010Ab<jats:sup>\u2212<\/jats:sup>; group B, 0.3\u00a0\u2264\u00a0TSH\u00a0&lt;\u00a02.5\u00a0mIU\/L and TPO\u2010Ab<jats:sup>+<\/jats:sup>; group C, 2.5\u00a0\u2264\u00a0TSH\u00a0&lt;\u00a04.2\u00a0mIU\/L, and TPO\u2010Ab<jats:sup>\u2212<\/jats:sup>; and group D, 2.5\u00a0\u2264\u00a0TSH\u00a0&lt;\u00a04.2\u00a0mIU\/L, TPO\u2010Ab<jats:sup>+<\/jats:sup>. The differences in ART cycles and pregnancy outcomes were analyzed between study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fertilization rate in group D (73%) was significantly lower than that in groups A (83% <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), B (84% <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), and C (82% <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). The biochemical pregnancy rates of groups B (7%) and D (12%) were significantly higher than those of group A (2%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.028 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017, respectively). TPO\u2010Ab was related to a higher biochemical pregnancy rate (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, OR\u00a0=\u00a05.311, 95% CI 1.859\u201015.169) and TSH over 2.5\u00a0mIU\/L was related to higher ICSI rate (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, OR\u00a0=\u00a01.759, 95% CI 1.250\u20102.476) by logistic regression analysis. The receiver operating characteristic (ROC) also verified the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The impacts of TSH\u00a0\u2265\u00a02.5\u00a0mIU\/L on the intracytoplasmic sperm injection (ICSI) rate, TSH\u00a0\u2265\u00a02.5\u00a0mIU\/L and TPO\u2010Ab<jats:sup>+<\/jats:sup> on the fertilization rate, and TPO\u2010Ab<jats:sup>+<\/jats:sup> on the biochemical pregnancy rate, rather than the effect on abortion, clinical pregnancy, and live birth, were emphasized.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13321","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T17:16:03Z","timestamp":1597511763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Does thyroid autoimmunity affect the reproductive outcome in women with thyroid autoimmunity undergoing assisted reproductive technology?"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9836-9791","authenticated-orcid":false,"given":"Qiaohua","family":"He","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center of People's Hospital of Zhengzhou University,Reproductive Medicine Center of Henan Provincial People's Hospital Henan Provincial People's Hospital of Henan University Zhengzhou China"},{"name":"Reproductive Medicine and Immunology Obstetrics and Gynecology Clinical Sciences Department Chicago Medical School Rosalind Franklin University of Medicine and Science Vernon Hills IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center of People's Hospital of Zhengzhou University,Reproductive Medicine Center of Henan Provincial People's Hospital Henan Provincial People's Hospital of Henan University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center of People's Hospital of Zhengzhou University,Reproductive Medicine Center of Henan Provincial People's Hospital Henan Provincial People's Hospital of Henan University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Fan","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center of People's Hospital of Zhengzhou University,Reproductive Medicine Center of Henan Provincial People's Hospital Henan Provincial People's Hospital of Henan University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center of People's Hospital of Zhengzhou University,Reproductive Medicine Center of Henan Provincial People's Hospital Henan Provincial People's Hospital of Henan University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8409-1645","authenticated-orcid":false,"given":"Joanne","family":"Kwak\u2010Kim","sequence":"additional","affiliation":[{"name":"Reproductive Medicine and Immunology Obstetrics and Gynecology Clinical Sciences Department Chicago Medical School Rosalind Franklin University of Medicine and Science Vernon Hills IL USA"},{"name":"Center for Cancer Cell Biology, Immunology and Infection Diseases Chicago Medical School Rosalind Franklin University of Medicine and Science Vernon Hills IL 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