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The aim of this study was to analyze the prevalence of inherited and acquired thrombophilia in a large cohort of RM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>Within a multicenter case\u2010control study, n\u00a0=\u00a0820 RM patients and n\u00a0=\u00a0141 controls were included. The prevalence of inherited and acquired thrombophilia including deficiency of protein C\/S and antithrombin, elevation of factor VIII activity, APC resistance including mutation in the factor V Leiden gene, mutation in the prothrombin gene and antiphospholipid antibodies were assessed. Further, we performed a meta\u2010analysis of the prevalence of thrombophilia in RM patients including studies between 01\/2000 and 01\/2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An antiphospholipid syndrome (APLS) was only present in RM patients. Increased factor VIII concentration was significantly more prevalent in controls (RM vs controls: 5.8% vs 11.0%). None of the other thrombophilia did differ significantly between RM patients and controls. The meta\u2010analysis revealed no significant difference in the occurrence of these thrombophilia between RM patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of inherited thrombophilia does not differ between RM patients and controls. When analyzing rare events like thrombophilia, a high number of patients are needed to obtain reliable results, which might explain contradictory findings in previous studies analyzing small cohorts of RM patients. Despite being less prevalent than previously described, we still recommend screening for APLS as it is associated with severe pregnancy complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13327","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T04:52:48Z","timestamp":1598676768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Recurrent miscarriage is not associated with a higher prevalence of inherited and acquired thrombophilia"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2981-4211","authenticated-orcid":false,"given":"Kilian","family":"Vomstein","sequence":"first","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Fertility Disorders Ruprecht\u2010Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Feil","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Goeggl","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Fertility Disorders Ruprecht\u2010Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Strowitzki","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Fertility Disorders Ruprecht\u2010Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Toth","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Reproductive Medicine Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben\u2010Jeremias","family":"Kuon","sequence":"additional","affiliation":[{"name":"Department of Gynecological Endocrinology and Fertility Disorders Ruprecht\u2010Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gco.0000194112.86051.26"},{"issue":"2","key":"e_1_2_8_3_1","article-title":"ESHRE guideline: recurrent pregnancy loss","volume":"2018","author":"Bender Atik R","year":"2018","journal-title":"Human Reproduction Open"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0586-4568"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-010-0011-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1316-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1242722"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.5.558"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12771-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12144"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000292"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002103420602"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.8755-8920.2001.450201.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.07.019"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.048"},{"key":"e_1_2_8_16_1","unstructured":"RCOG.Green\u2010top Guideline No. 17 The investigation and treatment of couples with recurrent first\u2010trimester and second\u2010trimester miscarriage. 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