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As a subtype of EVs, exosomes are made <jats:italic>via<\/jats:italic> unique biogenesis pathway and exhibit disparate functional and phenotypic characteristics. Functionally, exosomes transfer biological messages from donor cell to recipient cell, which makes exosomes as a novel therapeutic platform delivering therapeutic materials to the target tissue\/cell. Currently, both academia and industry try to develop exosome platform\u2010based therapeutics for disease management, some of which are already in clinical trials. 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