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CD can also be the underlying cause of several non\u2010gastrointestinal symptoms. This review summarizes evidence on the relationship between CD and gynecological\/obstetric disorders like reproductive failures. Although much has been reported on such a linkage, the pathogenic mechanisms remain unclear, especially those underlying extra\u2010gastrointestinal clinical manifestations. Studies conducted on celiac subjects presenting gynecological\/obstetric disorders have pointed to intestinal malabsorption, coagulation alterations, immune\u2010mediated tissue damage, and endometrial inflammation as the main responsible pathogenic mechanisms. Currently, however, the knowledge of such mechanisms is insufficient, and further studies are needed to gain a more thorough understanding of the matter.<\/jats:p>","DOI":"10.1111\/aji.13334","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T15:35:47Z","timestamp":1598888147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Celiac disease and reproductive failures: An update on pathogenic mechanisms"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-3335","authenticated-orcid":false,"given":"Nicoletta","family":"Di Simone","sequence":"first","affiliation":[{"name":"U.O.C. di Ostetricia e Patologia Ostetrica Dipartimento di Scienze della Salute della Donna del Bambino e di Sanit\u00e0 Pubblica Fondazione Policlinico Universitario A. 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