{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:31:58Z","timestamp":1761989518681,"version":"3.41.2"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Problem<\/jats:title><jats:p>Drug allergies are increasingly common. Immunological factors, implicated in many neurological diseases, also influence an individual's susceptibility. We sought to ascertain a possible association between maternal drug allergy and long\u2010term neurological\u2010related hospitalizations in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of study<\/jats:title><jats:p>This is a population\u2010based cohort analysis, comparing the long\u2010term risk of neurological\u2010related hospitalization, involving a predefined set of ICD9 codes as recorded in hospital records, of children born to mothers with and without drug allergies. Deliveries occurred between the years 1991 and 2014 in a tertiary medical center. Twin pregnancies, fetal malformations, and cases of perinatal mortality were excluded. A Kaplan\u2010Meier survival curve was constructed to compare cumulative neurological hospitalizations. A Cox proportional hazards model was used to control for time to event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 242\u00a0342 patients, 9714 with known drug allergy (4%). Offspring born to mothers with drug allergies had significantly more neurological hospitalizations compared to controls (4.2% vs 3.1%; <jats:italic>P\u00a0<\/jats:italic>\u2264\u00a0.001; Kaplan\u2010Meier log\u2010rank test <jats:italic>P\u00a0<\/jats:italic>\u2264\u00a0.001), specifically for psychiatric disorders including eating disorders (0.3% vs 0.2%;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), attention\u2010deficit\/hyperactivity disorder (0.124% vs 0.056%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008), emotional disorders (0.8% vs 0.5%; <jats:italic>P\u00a0<\/jats:italic>\u2264\u00a0.001), and movement disorders (2.3% vs 1.8%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). While controlling for birth year, gestational age, maternal age, maternal diabetes, hypertensive disorders, and cesarean delivery, using a Cox proportional hazards model, maternal drug allergy was found to be an independent risk factor for neurological hospitalization of the offspring (adjusted HR 1.3, 95% CI 1.19\u20101.45 <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Being born to a mother with known drug allergy is an independent risk factor for long\u2010term neurological hospitalization of the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13335","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T05:35:43Z","timestamp":1598938543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal known drug allergy and long\u2010term neurological hospitalizations of the offspring"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-1630","authenticated-orcid":false,"given":"Sharon","family":"Davidesko","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gali","family":"Pariente","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"The Department of Public Health Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"Safety of medicines \u2010 a guide to detecting and reporting adverse drug reactions \u2010 why health professionals need to take action: glossary.http:\/\/apps.who.int\/medicinedocs\/en\/d\/Jh2992e\/2.html. 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