{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:40:33Z","timestamp":1790019633220,"version":"4.0.1"},"reference-count":80,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endometriosis is a chronic disease that commonly affects women in their reproductive age. It has been reported that the infertility due to endometriosis is largely caused by pelvic adhesion, oocyte damage, and so on. There are several causes of endometriosis including bacterial infections, immunological abnormalities, epigenetics, and aberrant DNA methylation. The natural killer (NK) cells present in the peritoneal fluid express CD16 and CD56. They also express NK cell inhibitory receptors and activating receptors and usually work to eliminate endometrial cells in the retrograde menstruation. However, in women with endometriosis, the changes in these receptors and production of cytokines by NK cells cause the onset and progression of endometriosis. In this review, we have focused on the role of NK cells in pelvic endometriosis and presented the immunological abnormalities in endometriosis including the possibility of future treatment.<\/jats:p>","DOI":"10.1111\/aji.13342","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T19:10:30Z","timestamp":1600715430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Pelvic endometriosis and natural killer cell immunity"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-7458","authenticated-orcid":false,"given":"Atsushi","family":"Fukui","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuxian","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryu","family":"Takeyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ukita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8989-6998","authenticated-orcid":false,"given":"Yu","family":"Wakimoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayano","family":"Yamaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-3170","authenticated-orcid":false,"given":"Hiroaki","family":"Shibahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hyogo College of Medicine  Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh275"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-13726"},{"key":"e_1_2_15_4_1","first-page":"759","article-title":"Endometriosis and spontaneous abortion","volume":"7","author":"Daya S","year":"1996","journal-title":"Infertility Reprod Med Clin North America"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr026"},{"key":"e_1_2_15_6_1","first-page":"2885","article-title":"Bacterial contamination hypothesis: role of bacterial endotoxin and Toll\u2010like Receptor 4 (TLR4) in endometriosis","volume":"66","author":"Khan KN","year":"2014","journal-title":"Acta Obstet Gynaec Jpn"},{"key":"e_1_2_15_7_1","first-page":"2895","article-title":"Decreased immunosurveillance system in peritoneal cavity to retrograde menstruation in women with endometriosis","volume":"66","author":"Maeda N","year":"2014","journal-title":"Acta Obstet Gynaec Jpn"},{"key":"e_1_2_15_8_1","first-page":"2903","article-title":"Innovative therapeutic strategy for endometriosis targeting a novel subset of helper T cell","volume":"66","author":"Hirata T","year":"2014","journal-title":"Acta Obstet Gynaec Jpn"},{"key":"e_1_2_15_9_1","first-page":"2912","article-title":"Aberrant DNA methylation profile in ovarian endometriosis","volume":"66","author":"Yamagata Y","year":"2014","journal-title":"Acta Obstet Gynaec Jpn"},{"key":"e_1_2_15_10_1","first-page":"2919","article-title":"Epigenetics as the pathogenesis and therapeutic target of endometriosis","volume":"66","author":"Nasu K","year":"2014","journal-title":"Acta Obstet Gynaec Jpn"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614814"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)58162-X"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03112-6"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02021"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0618"},{"key":"e_1_2_15_16_1","first-page":"2513","article-title":"Inflammatory cytokines IL\u20106, IL\u201010, IL\u201013, TNF\u2010alpha and peritoneal fluid flora were associated with infertility in patients with endometriosis","volume":"22","author":"Wang XM","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12206"},{"key":"e_1_2_15_18_1","first-page":"151","article-title":"Serum and peritoneal fluid cytokine profiles in infertile women with endometriosis","volume":"16","author":"Tarokh M","year":"2019","journal-title":"Iranian J Immunol"},{"key":"e_1_2_15_19_1","first-page":"6","article-title":"The association between TNF\u2010alpha gene polymorphisms and endometriosis in an Iranian population","volume":"13","author":"Babaabasi B","year":"2019","journal-title":"Int J Fertil Steril"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04807-6"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166658"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.05.031"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.05.031"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.06.002"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.1.95"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138578"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.046"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem399"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.07.020"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00570-7"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02766132"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.07.014"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1997.tb00319.x"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1999.tb00456.x"},{"key":"e_1_2_15_35_1","first-page":"65","volume-title":"IFFS 2001 Selected Communications","author":"Fukui A","year":"2001"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.08.009"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.012"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)02964-8"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a135765"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2004.00170.x"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1994.tb00843.x"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.12.005"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu172"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2916070"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(15)30003-X"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.12.005"},{"key":"e_1_2_15_47_1","first-page":"220","article-title":"Successful heterotransplantation of human endometrium in SCID mice","volume":"83","author":"Aoki D","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55224-8"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00050.x"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54414-8"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91670-6"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex014"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/319675a0"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2019.102615"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.10076"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)01592-2"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.05.018"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00271.x"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00332.x"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917900"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199805)28:05<1611::AID-IMMU1611>3.0.CO;2-6"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200109)31:9<2680::AID-IMMU2680>3.0.CO;2-A"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/35059110"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13448"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2011.04.006"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2006.00431.x"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2012.01120.x"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12491"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.5.741"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101540"},{"key":"e_1_2_15_71_1","first-page":"154","article-title":"The expression of Natural Cytotoxicity Receptor on endometrial NK cells in women with endometriosis","volume":"38","author":"Funamizu A","year":"2017","journal-title":"J Japan Soc Endometriosis"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12259"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12062"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del516"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/329630a0"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00750.x"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01816-7"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.2.824"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.2.259"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2018.02.003"},{"key":"e_1_2_15_81_1","first-page":"96","article-title":"Change of NK cells by oral cintraceptive pills in women with endometriosis","volume":"37","author":"Funamizu A","year":"2016","journal-title":"J Japan Soc Endometriosis"}],"container-title":["American Journal of Reproductive Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aji.13342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aji.13342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:40:47Z","timestamp":1693546847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aji.13342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,21]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/aji.13342"],"URL":"https:\/\/doi.org\/10.1111\/aji.13342","archive":["Portico"],"relation":{},"ISSN":["1046-7408","1600-0897"],"issn-type":[{"value":"1046-7408","type":"print"},{"value":"1600-0897","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,21]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13342"}}