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Here, we analyzed available evidence pertaining to SARS\u2010CoV\u20102 infection, in early pregnancy, and in reproductive tissues. We searched PubMed and Embase databases in accordance with guidelines of Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) for publications from inception to June 4, 2020. Four reviewers screened titles and abstracts and obtained full\u2010text articles for analysis. Sixty\u2010two studies were included in the review. Biological plausibility for infection with SARS\u2010CoV\u20102 exists in testis, ovaries, and placenta as they express ACE2 receptor activity. In males, SARS\u2010CoV\u20102 infection could lead to functional abnormalities leading to spermatogenic failure and male infertility. In females, an alteration of the ACE2 cascade via SARS\u2010CoV\u20102 infection could lead to impairment in important follicular and luteal processes. There is also evidence of significant placental pathology in SARS\u2010CoV\u20102 infection, but it is unclear what effects there may be for early pregnancy, though available data suggest less severe effects compared to other respiratory virus outbreaks. Further investigation is needed regarding SARS\u2010CoV\u20102 in reproductive function and early pregnancy.<\/jats:p>","DOI":"10.1111\/aji.13351","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T02:12:44Z","timestamp":1600913564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Severe Acute Respiratory Syndrome Coronavirus 2 (SARS\u2010CoV\u20102) and its effect on gametogenesis and early pregnancy"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-4345","authenticated-orcid":false,"given":"Bhuchitra","family":"Singh","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Department of Gynecology and Obstetrics, Division of Reproductive Sciences &amp; Women\u2019s Health Research Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Gornet","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Department of Gynecology and Obstetrics, Division of Reproductive Sciences &amp; Women\u2019s Health Research Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Sims","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Department of Gynecology and Obstetrics, Division of Reproductive Sciences &amp; Women\u2019s Health Research Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwina","family":"Kisanga","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Knight","sequence":"additional","affiliation":[{"name":"American Society for Reproductive Medicine Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-376X","authenticated-orcid":false,"given":"James","family":"Segars","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Department of Gynecology and Obstetrics, Division of Reproductive Sciences &amp; Women\u2019s Health Research Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2004.054957"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.479"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.3982"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1604338"},{"issue":"1","key":"e_1_2_6_6_1","first-page":"157","article-title":"WHO Declares COVID\u201019 a Pandemic","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Biomed"},{"key":"e_1_2_6_7_1","unstructured":"World Health Organization.Coronavirus Disease (COVID\u20102019 Situation Reports.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/situation\u2010reports. 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