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Extracellular vesicles (EVs) are membrane\u2010enclosed, nano\u2010sized structures produced by cells to mediate cell to cell communication and modulate a diverse set of biological processes. Herein, we review the involvement of EVs in the process of embryo implantation and endometrial diseases. EVs have been isolated from uterine fluid, cultured endometrial epithelial\/stromal cells and trophectodermal cells. The endometrial epithelial and stromal\/decidual cell\u2010derived EVs and its cargo are internalized bythe trophoblast cells, and they regulate a diverse set of genes involved in adhesion, invasion and migration. Conversely, the embryo\u2010derived EVs and its cargo are internalized by epithelial and immune cells of the endometrium for biosensing and immunomodulation required for successful implantation. EVs have also been shown to play a role in infertility, recurrent implantation failure, endometriosis, endometritis and endometrial cancer. Further research should set a stage for EVs as non\u2010invasive \u201cliquid biopsy\u201d tools for assessment of endometrial health.<\/jats:p>","DOI":"10.1111\/aji.13360","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T16:52:50Z","timestamp":1602867170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Extracellular vesicles in embryo implantation and disorders of the endometrium"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4241-8646","authenticated-orcid":false,"given":"Anuradha","family":"Mishra","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biology Laboratory ICMR\u2010National Institute for Research in Reproductive Health Indian Council of Medical Research (ICMR) Mumbai 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