{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:47:20Z","timestamp":1790387240263,"version":"4.1.0"},"reference-count":88,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Problem<\/jats:title>\n                    <jats:p>Ascending placentitis is the leading cause of abortion in the horse. Interleukin (IL)\u20106 is considered predictive of placental infection in other species, but little is understood regarding its role in the pathophysiology of ascending placentitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method of study<\/jats:title>\n                    <jats:p>\n                      Sub\u2010acute ascending placentitis was induced via trans\u2010cervical inoculation of\n                      <jats:italic>S\u00a0zooepidemicus<\/jats:italic>\n                      , and various fluids\/serum\/tissues collected 8\u00a0days later. Concentrations of IL\u20106 were detected within fetal fluids and serum in inoculated (n\u00a0=\u00a06) and control (n\u00a0=\u00a06) mares. RNASeq was performed on the placenta (endometrium and chorioallantois) to assess transcripts relating to IL\u20106 pathways. IHC was performed for immunolocalization of IL\u20106 receptor (IL\u20106R) in the placenta.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL\u20106 concentrations increased in allantoic fluid following inoculation, with a trend toward an increase in amniotic fluid. Maternal serum IL\u20106 was increased in inoculated animals, while no changes were noted in fetal serum. mRNA expression of IL\u20106\u2010related transcripts within the chorioallantois indicates that IL\u20106 is activating the classical JAK\/STAT pathway, thereby acting as anti\u2010inflammatory, anti\u2010apoptotic, and pro\u2010survival. The IL\u20106R was expressed within the chorioallantois, indicating a paracrine signaling pathway of maternal IL\u20106 to fetal IL\u20106R.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IL\u20106 plays a crucial role in the placental response to induction of sub\u2010acute equine ascending placentitis, and this could be noted in amniotic fluid, allantoic fluid, and maternal serum. Additionally, IL\u20106 is acting as anti\u2010inflammatory in this disease, potentially altering disease progression, impeding abortion signals, and assisting with the production of a viable neonate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aji.13363","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T08:54:41Z","timestamp":1603529681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Interleukin\u20106 pathobiology in equine placental infection"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0518-4809","authenticated-orcid":false,"given":"Carleigh E.","family":"Fedorka","sequence":"first","affiliation":[{"name":"Department of Veterinary Science University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten E.","family":"Scoggin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"El\u2010Sheikh Ali","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Kentucky Lexington KY USA"},{"name":"Department of Theriogenology University of Mansoura Dakahlia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavahn C.","family":"Loux","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Kentucky Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Dini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Kentucky Lexington KY USA"},{"name":"Department of Veterinary Medicine Ghent University Merelbeke Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats H. 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