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This condition is characterized by fibrin\u2010like necrosis of the blood vessel walls, the accumulation of macrophages containing fat (foam cells), and the infiltration of macrophages around blood vessels. Uteroplacental acute atherosis is rare in normal pregnancy but occurs more frequently in patients with pregnancy complications, including preeclampsia, spontaneous preterm labor, preterm prelabor rupture of membranes, mid\u2010trimester spontaneous abortion, fetal death, and small\u2010for\u2010gestational age. It is believed that the mechanisms underlying the development of uteroplacental acute atherosis are related to the incomplete physiological transformation of spiral arteries, placental inflammation, abnormal lipid metabolism, and oxidative stress. In this review, we describe the pathogenesis of uteroplacental acute atherosis to provide reference guidelines for the future prevention and treatment of uteroplacental acute atherosclerotic disease.<\/jats:p>","DOI":"10.1111\/aji.13397","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T14:34:56Z","timestamp":1612535696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pathogenesis of uteroplacental acute atherosis: An update on current research"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-2053","authenticated-orcid":false,"given":"Shu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Guangzhou Women &amp; Children Medical Center Guangzhou Medical University Guangzhou 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