{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:53:50Z","timestamp":1793944430396,"version":"4.8.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J Rep Immunol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Problem<\/jats:title><jats:p>Celiac disease is an autoimmune disease, patients with celiac have increased risk for infections, and offspring of celiac mothers have increased morbidity. The aim of the study was to assess long\u2010term infectious morbidity among offspring of pregnant women with celiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method of Study<\/jats:title><jats:p>A population\u2010based cohort study was conducted, including all singleton deliveries between the years 1991\u20132014 at a tertiary medical center. The offsprings were subdivided into two groups: offsprings of mothers with and without celiac disease. Data on demographics, maternal, perinatal, and long\u2010term hospitalizations for infectious morbidity were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period there were 210 (0.09%) deliveries of mothers with celiac, and they were compared to 242170 (99.91%) deliveries of non\u2010celiac mothers. Cumulative infectious morbidity was significantly higher in offspring of mothers with celiac compared to offspring of mothers without celiac (Kaplan\u2010Meier, log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). Specifically, among the offspring of mothers with celiac significantly higher rates of bacteremia was noted (1.0% vs. 0.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), and infections of the central nervous system (1% vs. 0.2%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028). In the Cox multivariable model which accounted for confounding variables, being born to mothers with celiac disease was associated with significantly increased risk for long\u2010term infectious morbidity of the offspring (adjusted HR\u00a0=\u00a01.6, 95% CI 1.165\u20132.357, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal celiac disease is an independent risk factor for long\u2010term infectious morbidity for the offspring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aji.13399","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T17:59:52Z","timestamp":1612547992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal celiac disease and the risk for long\u2010term infectious morbidity of the offspring"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4844-3308","authenticated-orcid":false,"given":"Naim","family":"Abu\u2010Freha","sequence":"first","affiliation":[{"name":"The Institute of Gastroenterology and Hepatology The Faculty of Health Sciences Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"The Department of Public Health Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aerin","family":"Philip","sequence":"additional","affiliation":[{"name":"Medical School for International Health Faculty of Health Sciences, Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyal","family":"Sheiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva 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